{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:00:07Z","timestamp":1787508007987,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T00:00:00Z","timestamp":1423353600000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Antineuronal antibodies are autoantibodies directed against antigens in the central and\/or peripheral nervous system. The aim of this study was to compare the prevalence of these antibodies in CRPS patients with the normal values of those antibodies in the healthy population.   \nTwenty seven (33%) of the 82 CRPS patients of whom serum was available showed a positive ANA test. This prevalence is significantly higher than in the general population. Six patients (7.3%) showed a positive result for typical antineuronal antibodies. This proportion, however, does not deviate from that in the general population. Our findings suggest that autoantibodies may be associated with the pathophysiology of CRPS, at least in a subset of patients. Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS.<\/jats:p>","DOI":"10.1155\/2015\/718201","type":"journal-article","created":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T16:01:41Z","timestamp":1423411301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4306-654X","authenticated-orcid":false,"given":"Maaike","family":"Dirckx","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco W. J.","family":"Schreurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"de Mos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk L.","family":"Stronks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J. P. M.","family":"Huygen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,8]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2009.00262.x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92877-v"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/09629350210307"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2007.10.010"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ajp.0b013e31822efe30"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.008"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199409000-00007"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.53.6.1350"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.05.015"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.07.002"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2008\/11\/133"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.01.018"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200106000-00002"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2006.01.006"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000143066.58498.BA"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.03.009"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.10.005"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-3-201002020-00006"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.10.015"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.6.581"},{"key":"e_1_2_7_21_2","first-page":"257","article-title":"Systemic autoimmune diseases: appropriate serological diagnostics","volume":"31","author":"Hooijkaas H.","year":"2006","journal-title":"Nederlands Tijdschrift voor Klinische Chemie en Laboratoriumgeneeskunde"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.99"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(99)00011-1"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203863"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.45.10.1937"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3282"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.06.019"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1313.029"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339900800611"},{"key":"e_1_2_7_30_2","first-page":"1774","article-title":"Recurrent reflex sympathetic dystrophy as a manifestation of systemic lupus erythematosus","volume":"20","author":"Ostrov B. E.","year":"1993","journal-title":"The Journal of Rheumatology"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21692"},{"key":"e_1_2_7_32_2","first-page":"395","article-title":"Roles of autoantibodies in central nervous system injury","volume":"11","author":"Zhang Y.","year":"2011","journal-title":"Discovery medicine"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.07.008"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20400"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/718201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2015\/718201.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2015\/718201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T17:49:45Z","timestamp":1722880185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2015\/718201"}},"subtitle":[],"editor":[{"given":"Dianne","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1155\/2015\/718201"],"URL":"https:\/\/doi.org\/10.1155\/2015\/718201","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2014-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"718201"}}