{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:25:30Z","timestamp":1776288330924,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271964"],"award-info":[{"award-number":["81271964"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>This study was aimed at investigating the pathogenesis of oxidative stress in steroid-induced avascular necrosis of the femoral head (SANFH) and at exploring the mechanism and protective effects of<jats:italic>Panax notoginseng<\/jats:italic>saponins (PNS) on early SANFH.<jats:italic>Methods.<\/jats:italic>80 adult New Zealand rabbits were randomly divided into control group, model group, and PNS group. In model group, equine serum was injected into auricular vein; then methylprednisolone was injected into gluteus. In PNS group, PNS was applied for 14 consecutive days before methylprednisolone management. At different time points, serum and femoral heads were prepared for T-AOC, SOD, GSH-PX, \u00b7OH, and MDA determination. Two weeks after steroid management, all femoral heads were assessed with MRI and HE staining.<jats:italic>Results.<\/jats:italic>Typical early osteonecrosis symptoms were observed in model group. Our results showed that PNS could significantly ameliorate the decrease of T-AOC level, improve SOD and GSH-PX activity, suppress \u00b7OH ability, and augment MDA level. Besides, PNS improved MRI and pathological changes of the femoral head, markedly reducing the incidence of osteonecrosis.<jats:italic>Conclusion.<\/jats:italic>Based on our research, we found oxidative stress played a positive role in the occurrence of SANFH where reactive oxygen species was the direct cause. PNS could protect rabbits against early steroid-induced osteonecrosis of femoral head by its antioxidative effect.<\/jats:p>","DOI":"10.1155\/2015\/719370","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T17:08:16Z","timestamp":1426525696000},"page":"1-10","source":"Crossref","is-referenced-by-count":17,"title":["Early Steroid-Induced Osteonecrosis of Rabbit Femoral Head and<i>Panax notoginseng<\/i>Saponins: Mechanism and Protective Effects"],"prefix":"10.1155","volume":"2015","author":[{"given":"Hui","family":"Qiang","sequence":"first","affiliation":[{"name":"The Second Department of Orthopaedics, Shaanxi Provincial People\u2019s Hospital, The Third Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710068, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huitong","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Department of Orthopaedics, Shaanxi Provincial People\u2019s Hospital, The Third Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710068, China"},{"name":"The First Department of Orthopaedics, Fuzhou Second Hospital of Xiamen University, Fuzhou, Fujian 350007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Ling","sequence":"additional","affiliation":[{"name":"The Second Department of Orthopaedics, Shaanxi Provincial People\u2019s Hospital, The Third Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710068, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunzheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Department of Orthopaedics, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Department of Orthopaedics, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi 710004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"61","volume":"277","year":"1992","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"3","key":"2","first-page":"346","volume":"69","year":"1987","journal-title":"The Journal of Bone & Joint Surgery\u2014British Volume"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2106\/00004623-198567050-00010","volume":"67","year":"1985","journal-title":"Journal of Bone and Joint Surgery. 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