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Therefore, we investigated whether Rh1 could enhance the effect of dexamethasone (Dex) in the treatment of MRL\/lpr mice. MRL\/lpr mice were treated with vehicle, Dex, Rh1, or Dex + Rh1 for 4 weeks. Dex significantly reduced the proteinuria and anti-dsDNA and anti-ANA autoantibodies. The levels of proteinuria and anti-dsDNA and anti-ANA autoantibodies were further decreased in Dex + Rh1 group. Dex, Rh1, or Dex + Rh1 did not alter the proportion of CD4+ splenic lymphocytes, whereas the proportion of CD8+ splenic lymphocytes was significantly increased in Dex and Dex + Rh1 groups. Dex + Rh1 significantly decreased the ratio of CD4+\/CD8+ splenic lymphocytes compared with control. Con A-induced CD4+ splenic lymphocytes proliferation was increased in Dex-treated mice and was inhibited in Dex + Rh1-treated mice. Th1 cytokine IFN-<jats:italic>\u03b3<\/jats:italic>mRNA was suppressed and Th2 cytokine IL-4 mRNA was increased by Dex. The effect of Dex on IFN-<jats:italic>\u03b3<\/jats:italic>and IL-4 mRNA was enhanced by Rh1. In conclusion, our data suggest that Rh1 may enhance the effect of Dex in the treatment of MRL\/lpr mice through regulating CD4+ T cells activation and Th1\/Th2 balance.<\/jats:p>","DOI":"10.1155\/2015\/727650","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T05:39:29Z","timestamp":1428298769000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Ginsenoside Rh1 Improves the Effect of Dexamethasone on Autoantibodies Production and Lymphoproliferation in MRL\/lpr Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yinglu","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, 401 Hospital of the Chinese People\u2019s Liberation Army, Qingdao, Shandong 266071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, 401 Hospital of the Chinese 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