{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:38:39Z","timestamp":1740152319814,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100008990","name":"Universit\u00e9 de Lorraine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Bioinformatics"],"published-print":{"date-parts":[[2015,10,20]]},"abstract":"<jats:p>Statistical features  are widely used in radiology for tumor heterogeneity assessment using magnetic resonance (MR) imaging technique. In this paper, feature selection based on decision tree is examined to determine the relevant subset of glioblastoma (GBM) phenotypes in the statistical domain. To discriminate between active tumor (<jats:italic>v<\/jats:italic>AT) and edema\/invasion (<jats:italic>vE<\/jats:italic>) phenotype, we selected the significant features using analysis of variance (ANOVA) with <jats:italic>p<\/jats:italic> value &lt; 0.01. Then, we implemented the decision tree to define the optimal subset features of phenotype classifier. Na\u00efve Bayes (NB), support vector machine (SVM), and decision tree (DT) classifier were considered to evaluate the performance of the feature based scheme in terms of its capability to discriminate <jats:italic>v<\/jats:italic>AT from <jats:italic>vE<\/jats:italic>. Whole nine features were statistically significant to classify the <jats:italic>v<\/jats:italic>AT from <jats:italic>vE<\/jats:italic> with <jats:italic>p<\/jats:italic> value &lt; 0.01. Feature selection based on decision tree showed the best performance by the comparative study using full feature set. The feature selected showed that the two features Kurtosis and Skewness achieved a highest range value of 58.33\u201375.00% accuracy classifier and 73.88\u201392.50% AUC. This study demonstrated the ability of statistical features to provide a quantitative, individualized measurement of glioblastoma patient and assess the phenotype progression.<\/jats:p>","DOI":"10.1155\/2015\/728164","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T21:08:17Z","timestamp":1445375297000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["High-Throughput Quantification of Phenotype Heterogeneity Using Statistical Features"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ahmad","family":"Chaddad","sequence":"first","affiliation":[{"name":"Laboratory of Conception, Optimization and Modelling of Systems, University of Lorraine, 7 rue Marconie, Metz, 57070 Lorraine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camel","family":"Tanougast","sequence":"additional","affiliation":[{"name":"Laboratory of Conception, Optimization and Modelling of Systems, University of Lorraine, 7 rue Marconie, Metz, 57070 Lorraine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-2-165"},{"issue":"1","key":"2","first-page":"32","volume":"40","year":"2013","journal-title":"Journal of Registry Management"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2174\/157340507782446241"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0179-x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4236\/jbise.2013.611128"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/868031"},{"issue":"2","key":"7","first-page":"39","volume":"8","year":"2011","journal-title":"WSEAS Transactions on Biology and Biomedicine"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.9.096007"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1117\/1.2194018"},{"year":"1984","key":"13"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.12.9545"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.12.9926"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2003.10.021"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1109\/5254.708428"},{"year":"2014","key":"19"},{"year":"2007","key":"20"},{"year":"1993","key":"21"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/nature12625"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(03)00212-1"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/nature07385"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-10-8"}],"container-title":["Advances in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2015\/728164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2015\/728164.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2015\/728164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:09:48Z","timestamp":1607472588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/abi\/2015\/728164\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":21,"alternative-id":["728164","728164"],"URL":"https:\/\/doi.org\/10.1155\/2015\/728164","relation":{},"ISSN":["1687-8027","1687-8035"],"issn-type":[{"type":"print","value":"1687-8027"},{"type":"electronic","value":"1687-8035"}],"subject":[],"published":{"date-parts":[[2015,10,20]]}}}