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Below we describe a patient who developed an unusual complication of tyrosine kinase inhibitor therapy: thyrotoxicosis due to destructive thyroiditis. We review the pathophysiology of tyrosine kinase inhibitor-induced thyroid dysfunction particularly with regard to new second-generation tyrosine kinase inhibitors.<\/jats:p>","DOI":"10.1155\/2015\/736092","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T21:20:57Z","timestamp":1431033657000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Nilotinib-Associated Destructive Thyroiditis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Suhalia","family":"Bakerywala","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica D.","family":"Schwarcz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Valiquette","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene A.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2126"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1530\/eje-08-0648"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0456"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra044389"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-7-753"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0586"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.5.618"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0251"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.4"},{"issue":"12","key":"11","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.6004\/jnccn.2014.0169","volume":"12","year":"2014","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)60421-9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1530\/eje-14-0788"},{"issue":"7, article 49","key":"14","volume":"31","year":"2014","journal-title":"Medical Oncology"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2015\/736092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2015\/736092.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2015\/736092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T11:09:25Z","timestamp":1498216165000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crie\/2015\/736092\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":13,"alternative-id":["736092","736092"],"URL":"https:\/\/doi.org\/10.1155\/2015\/736092","relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}