{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:35:01Z","timestamp":1767998101936,"version":"3.49.0"},"reference-count":20,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Universitat Autonoma de Barcelona"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The aim of this study was to find a proper experimental design and to evaluate n-butyl-2-cyanoacrylate (Histoacryl) as a fixation method for a light-weight and large pore PP mesh (<jats:italic>Synthetic PP Mesh-1<\/jats:italic>) using the sheep as an animal model.<jats:italic>Methods<\/jats:italic>. Posterior vaginal implantation by means of episiotomy was used to implant 8 ewes which were evaluated macroscopically and histologically at 3 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>4<\/mml:mn><\/mml:math>) and 6 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>4<\/mml:mn><\/mml:math>) post-surgery. In previous pilot studies anterior vaginal implantation was evaluated, as well as different synthetic mesh materials, sizes and fixation methods (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:math>to 3) during three weeks. In all cases a clinical evaluation of the animal was performed.<jats:italic>Results<\/jats:italic>. A reduction in the mesh size (<jats:italic>Synthetic PP Mesh-1<\/jats:italic>) together with precise application of the surgical glue Histoacryl to fix the mesh yielded significantly better histocompatibility results (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) compared to larger size or other fixation methods.<jats:italic>Conclusion<\/jats:italic>. The combination of<jats:italic>Synthetic PP Mesh-1<\/jats:italic>with Histoacryl offered a high degree of graft integration without vaginal ulceration and a minimal foreign body reaction, being the sheep a proper animal model to test these types of medical devices.<\/jats:p>","DOI":"10.1155\/2015\/737683","type":"journal-article","created":{"date-parts":[[2015,6,28]],"date-time":"2015-06-28T17:03:16Z","timestamp":1435510996000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Fixation of Light Weight Polypropylene Mesh with n-Butyl-2-cyanocrylate in Pelvic Floor Surgery: Experimental Design Approach in Sheep for Effectiveness Evaluation"],"prefix":"10.1155","volume":"2015","author":[{"given":"Sandra","family":"Barbosa","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"},{"name":"Integrated Services of Laboratory Animals, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Nieves","sequence":"additional","affiliation":[{"name":"B. Braun Surgical S.A., Rubi, 08191 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Cepeda","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"},{"name":"Integrated Services of Laboratory Animals, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Marco","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Anatomy, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Weis","sequence":"additional","affiliation":[{"name":"B. Braun Surgical S.A., Rubi, 08191 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Turon","sequence":"additional","affiliation":[{"name":"B. Braun Surgical S.A., Rubi, 08191 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patri","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"},{"name":"Integrated Services of Laboratory Animals, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08153 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0902-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.10.602"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0b013e3181898ba9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/01.aog.0000165824.62167.c1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00058-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1384-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.049"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/bf02426382"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00930.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.02.022"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-006-0291-7"},{"key":"13","first-page":"2","volume":"12","year":"2011","journal-title":"Neurourology and Urodynamics"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-006-0176-9"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12081"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1440-1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.09.031"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2010.09.004"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-2970-z"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-011-0887-9"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.05.003"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/737683.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/737683.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/737683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T21:07:03Z","timestamp":1471554423000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/737683\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":20,"alternative-id":["737683","737683"],"URL":"https:\/\/doi.org\/10.1155\/2015\/737683","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}