{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:18:06Z","timestamp":1789651086625,"version":"4.0.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":214,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"MHCR for Conceptual Development of Research Organization","award":["023728"],"award-info":[{"award-number":["023728"]}]},{"name":"MHCR for Conceptual Development of Research Organization","award":["264 511"],"award-info":[{"award-number":["264 511"]}]},{"name":"SVV Project","award":["023728"],"award-info":[{"award-number":["023728"]}]},{"name":"SVV Project","award":["264 511"],"award-info":[{"award-number":["264 511"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. <jats:italic>Methods.<\/jats:italic> PGRN levels were evaluated in patients with RA (<jats:italic>n<\/jats:italic> = 47) and OA (<jats:italic>n<\/jats:italic> = 42) and healthy controls (<jats:italic>n<\/jats:italic> = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C\u2010reactive protein (CRP), disease activity score (DAS28\u2010CRP), and health assessment questionnaire (HAQ) was studied. <jats:italic>Results<\/jats:italic>. Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 \u00b1 100.2 and 221.5 \u00b1 102.5 versus 128.1 \u00b1 34.7\u2009ng\/mL; <jats:italic>P<\/jats:italic> &lt; 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 \u00b1 275.3 versus 241.4 \u00b1 165.2\u2009ng\/mL; <jats:italic>P<\/jats:italic> = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (<jats:italic>r<\/jats:italic> = 0.327, <jats:italic>P<\/jats:italic> = 0.049) and HAQ score (<jats:italic>r<\/jats:italic> = 0.323, <jats:italic>P<\/jats:italic> = 0.032), while synovial fluid PGRN correlated only with HAQ (<jats:italic>r<\/jats:italic> = 0.310, <jats:italic>P<\/jats:italic> = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies. <jats:italic>Conclusions<\/jats:italic>. This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.<\/jats:p>","DOI":"10.1155\/2015\/740357","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T06:28:50Z","timestamp":1438669730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Lucie","family":"Andr\u00e9s 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