{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:25:40Z","timestamp":1760898340575,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Foundation of Ministry of Education of Hubei Province","award":["D20142102","2013PY02","2013JJXM011"],"award-info":[{"award-number":["D20142102","2013PY02","2013JJXM011"]}]},{"name":"Foundation of Taihe Hospital","award":["D20142102","2013PY02","2013JJXM011"],"award-info":[{"award-number":["D20142102","2013PY02","2013JJXM011"]}]},{"name":"Foundation of Taihe Hospital","award":["D20142102","2013PY02","2013JJXM011"],"award-info":[{"award-number":["D20142102","2013PY02","2013JJXM011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Certain studies have previously explored the association between the estrogen receptor-<jats:italic>\u03b1<\/jats:italic>(ER-<jats:italic>\u03b1<\/jats:italic>) gene polymorphisms and periodontitis susceptibility, although the current results are controversial. The present study, using meta-analysis, aimed to investigate the nature of the genetic susceptibility of the ER-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>for developing periodontitis.<jats:italic>Methods<\/jats:italic>. A comprehensive literature search of PubMed, Embase, CNKI, and Wanfang databases was conducted up to January 8, 2015. Statistical manipulation was performed using Stata version 13.0 software. Odds ratios (ORs) and corresponding 95% confident intervals (CIs) were calculated to estimate the association in five genetic models.<jats:italic>Results<\/jats:italic>. A total of 17 eligible case-control studies from seven identified publications consisting of nine studies for the XbaI polymorphism and eight studies for the PvuII polymorphism were included in the meta-analysis. We found elevated risk of periodontitis in XbaI XX genotype carriers. Moreover, subgroup analyses demonstrated increased risk for chronic periodontitis of XbaI XX genotype carriers, specifically in the Chinese Han female population. No significant association was observed between PvuII polymorphism and periodontitis.<jats:italic>Conclusion<\/jats:italic>. Current evidence indicated that the homozygote (XX) genotype of ER-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population.<\/jats:p>","DOI":"10.1155\/2015\/741972","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T21:01:54Z","timestamp":1448398914000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Association between Estrogen Receptor-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Hong","family":"Weng","sequence":"first","affiliation":[{"name":"Center for Evidence-Based Medicine and 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