{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:15:22Z","timestamp":1789064122340,"version":"build-2803163510"},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Our aim was to assess the prevalence of subclinical diabetic cardiomyopathy, occurring among diabetic patients without hypertension or coronary artery disease (CAD).<jats:italic>Methods<\/jats:italic>. 656 asymptomatic patients with type 2 diabetes for 14 \u00b1 8 years (359 men, 59.7 \u00b1 8.7 years old, HbA1c 8.7 \u00b1 2.1%) and at least one cardiovascular risk factor had a cardiac echography at rest, a stress cardiac scintigraphy to screen for silent myocardial ischemia (SMI), and, in case of SMI, a coronary angiography to screen for silent CAD.<jats:italic>Results<\/jats:italic>. SMI was diagnosed in 206 patients, and 71 of them had CAD. In the 157 patients without hypertension or CAD, left ventricular hypertrophy (LVH: 24.1%) was the most frequent abnormality, followed by left ventricular dilation (8.6%), hypokinesia (5.3%), and systolic dysfunction (3.8%). SMI was independently associated with hypokinesia (odds ratio 14.7 [2.7\u201381.7],<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) and systolic dysfunction (OR 114.6 [1.7\u20137907],<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), while HbA1c (OR 1.9 [1.1\u20133.2],<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and body mass index (OR 1.6 [1.1\u20132.4],<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) were associated with systolic dysfunction. LVH was more prevalent among hypertensive patients and hypokinesia in the patients with CAD.<jats:italic>Conclusion<\/jats:italic>. In asymptomatic type 2 diabetic patients, diabetic cardiomyopathy is highly prevalent and is predominantly characterized by LVH. SMI, obesity, and poor glycemic control contribute to structural and functional LV abnormalities.<\/jats:p>","DOI":"10.1155\/2015\/743503","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T17:08:51Z","timestamp":1431536931000},"page":"1-8","source":"Crossref","is-referenced-by-count":32,"title":["Evidence for a Specific Diabetic Cardiomyopathy: An Observational Retrospective Echocardiographic Study in 656 Asymptomatic Type 2 Diabetic Patients"],"prefix":"10.1155","volume":"2015","author":[{"given":"Isabelle","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Physiology, AP-HP, Jean Verdier Hospital, 93 143 Bondy, France"},{"name":"Sorbonne Paris Cit\u00e9-Universit\u00e9 Paris 13, UFR SMBH, EA 23-63, 93 017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Cosson","sequence":"additional","affiliation":[{"name":"AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, Universit\u00e9 Paris 13, CRNH-IdF, CINFO, 93 143 Bondy, France"},{"name":"Sorbonne Paris Cit\u00e9-Universit\u00e9 Paris 13, UMR U1153 Inserm\/U1125 Inra\/Cnam, 93 017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Tuan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, Universit\u00e9 Paris 13, CRNH-IdF, CINFO, 93 143 Bondy, France"},{"name":"Sorbonne Paris Cit\u00e9-Universit\u00e9 Paris 13, UMR U1153 Inserm\/U1125 Inra\/Cnam, 93 017 Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Banu","sequence":"additional","affiliation":[{"name":"AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, Universit\u00e9 Paris 13, CRNH-IdF, CINFO, 93 143 Bondy, 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