{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:38:53Z","timestamp":1789663133288,"version":"4.0.1"},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Diabetes mellitus is metabolic syndrome that causes disability, early death, and many other complications. Currently insulin and many synthetic drugs are used in diabetes treatment. However, these pharmaceutical drugs are too expensive particularly for sub-Saharan population in addition to their undesirable side effects. The present study was aimed to evaluate antidiabetic effect and toxicity level of<jats:italic>Artemisia afra<\/jats:italic>which was collected from its natural habitat in Bale Zone, around Goba town, 455\u2009km southeast of Addis Ababa. Air dried aerial parts of<jats:italic>Artemisia afra<\/jats:italic>were separately extracted with both distilled water and 95% methanol. Oral acute toxicity test was conducted on healthy Swiss albino mice. Antidiabetic effect of the aqueous and methanolic extracts of<jats:italic>Artemisia afra<\/jats:italic>was separately evaluated on alloxan induced diabetic mice at doses of 500, 750, and 1000\u2009mg\/Kg body weight orally. The results indicate that mean lethal dose (LD<jats:sub>50<\/jats:sub>) for aqueous extract of<jats:italic>Artemisia afra<\/jats:italic>was 9833.4\u2009mg\/Kg. Blood glucose level was significantly decreased by 24% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>) and 56.9% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0004<\/mml:mn><\/mml:math>) in groups that received aqueous extract of<jats:italic>Artemisia afra<\/jats:italic>at dose of 500\u2009mg\/Kg and 750\u2009mg\/Kg, respectively. The methanolic extract of<jats:italic>Artemisia afra<\/jats:italic>also significantly lowered blood glucose by 49.8% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>) at doses of 1000\u2009mg\/kg on the 5th\u2009hr. Aqueous extract of<jats:italic>Artemisia afra<\/jats:italic>was regarded as nontoxic and safe since its LD<jats:sub>50<\/jats:sub>was found above 5000\u2009mg\/Kg. Aqueous extract showed higher effect at relatively lower dose as compared to methanolic extract. The aqueous extract was screened positive for phytochemicals like flavonoids, polyphenols, and tannins that were reported to have antioxidant activity.<\/jats:p>","DOI":"10.1155\/2015\/752486","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T21:04:15Z","timestamp":1438808655000},"page":"1-5","source":"Crossref","is-referenced-by-count":25,"title":["Hypoglycemic Effect of Aqueous and Methanolic Extract of<i>Artemisia afra<\/i>on Alloxan Induced Diabetic Swiss Albino Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Idris Ahmed","family":"Issa","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Mekelle University, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Hussen Bule","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"9","key":"1","first-page":"99","volume":"1","year":"2011","journal-title":"Journal of Applied Pharmaceutical Science"},{"issue":"8","key":"2","first-page":"969","volume":"41","year":"2012","journal-title":"Sains Malaysiana"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/103760"},{"issue":"7","key":"4","first-page":"41","volume":"13","year":"2013","journal-title":"Global Journal of Medical Research"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v13i9.9"},{"issue":"1","key":"6","first-page":"11","volume":"2","year":"2012","journal-title":"Asian Journal of Plant Science & Research"},{"issue":"1","key":"7","first-page":"26","volume":"5","year":"2015","journal-title":"European Journal of Experimental Biology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.691"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2005.9698880"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/14786410600603783"},{"key":"11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0022-4804(83)90034-3","volume":"35","year":"1983","journal-title":"Journal of Surgical Research"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(01)00407-x"},{"issue":"8","key":"13","first-page":"670","volume":"47","year":"2006","journal-title":"Singapore Medical Journal"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(03)00208-3"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.03.049"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.11.009"},{"issue":"3","key":"17","first-page":"124","volume":"3","year":"2003","journal-title":"African Hhealth Sciences"},{"key":"18","year":"2002"},{"key":"19","year":"1996"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/752486.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/752486.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2015\/752486.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T17:03:28Z","timestamp":1498237408000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2015\/752486\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"alternative-id":["752486","752486"],"URL":"https:\/\/doi.org\/10.1155\/2015\/752486","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}