{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:26:22Z","timestamp":1769840782888,"version":"3.49.0"},"reference-count":36,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Nonfunctioning pituitary adenomas (NFPAs) are the most common benign lesions of the pituitary gland.<jats:italic>Objective<\/jats:italic>. To describe our experience with the management of NFPA.<jats:italic>Study Design and Methods<\/jats:italic>. Retrospective evaluation of NFPA patients managed between 2008 and 2013. We analyzed data regarding clinical presentation, imaging diagnosis, hormonal status, surgical, radiotherapeutic, and pharmacological treatment, and outcome.<jats:italic>Results<\/jats:italic>. 485 patients (54% men, mean age<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>53<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>14<\/mml:mn><\/mml:math>years) were followed for a median of 6.5 years. Visual field abnormalities and headaches were the presenting complaints in 87% and 66%, respectively. The diagnosis of NFPA was made incidentally in 6.2%, and 8% presented with clinical evidence of apoplexy. All patients harbored macroadenomas, with a median volume of 10306 mm<jats:sup>3<\/jats:sup>; 57.9% had supra- or parasellar invasion and 19.6% had tumors larger than 4\u2009cm. Central hypothyroidism, hypogonadism, and hypocortisolism were present in 47.2%, 35.9%, and 27.4%, respectively. Surgical resection was performed at least once in 85.7%. Tumor persistence was documented in 27% and was related to the size and invasiveness of the lesion. In selected cases, radiotherapy proved to be effective in controlling or preventing tumor growth.<jats:italic>Conclusions<\/jats:italic>. The diagnosis and treatment of NFPA are complex and require a multidisciplinary approach.<\/jats:p>","DOI":"10.1155\/2015\/756069","type":"journal-article","created":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T21:01:32Z","timestamp":1423429292000},"page":"1-7","source":"Crossref","is-referenced-by-count":53,"title":["Clinical Characteristics and Treatment Outcome of 485 Patients with Nonfunctioning Pituitary Macroadenomas"],"prefix":"10.1155","volume":"2015","author":[{"given":"Guadalupe","family":"Vargas","sequence":"first","affiliation":[{"name":"Endocrinology Service, Experimental Endocrinology Unit, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baldomero","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Endocrinology Service, Experimental Endocrinology Unit, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, 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