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Recently, several computational methods have been proposed based on protein sequence-based and structure-based information, but the information of their related proteins has not been used until now. In this paper, we proposed using protein \u201csequence space\u201d to explore this information and used it to predict high-risk types of HPVs. The proposed method was tested on 68 samples with known HPV types and 4 samples without HPV types and further compared with the available approaches. The results show that the proposed method achieved the best performance among all the evaluated methods with accuracy 95.59% and<jats:italic>F1<\/jats:italic>-score 90.91%, which indicates that protein \u201csequence space\u201d could potentially be used to improve prediction of high-risk types of HPVs.<\/jats:p>","DOI":"10.1155\/2015\/756345","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T21:05:24Z","timestamp":1429563924000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Prediction of High-Risk Types of Human Papillomaviruses Using Statistical Model of Protein \u201cSequence Space\u201d"],"prefix":"10.1155","volume":"2015","author":[{"given":"Cong","family":"Wang","sequence":"first","affiliation":[{"name":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Yabing","family":"Hai","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Zhejiang Sci-Tech University, 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