{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:05:00Z","timestamp":1696493100175},"reference-count":30,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special","doi-asserted-by":"crossref","award":["2011-2008-02","2013BAI12B01-4"],"award-info":[{"award-number":["2011-2008-02","2013BAI12B01-4"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. We aim to explore urinary biomarkers that could monitor CAD in type 2 diabetic patients.<jats:italic>Materials and Methods<\/jats:italic>. Urine samples from two groups, twenty-eight type 2 diabetic patients with coexisting CAD and thirty type 2 diabetic patients without CAD, were purified by MB-WCX and then analyzed by MALDI-TOF-MS. Subsequently, we compared the urinary peptide signatures of the two groups by use of ClinProTools2.1 and evaluated the potential ability of the differently expressed peptides to distinguish type 2 diabetic patients with coexisting CAD from type 2 diabetic patients without CAD by ROC analysis. Finally, the differently expressed peptides were identified by nanoliquid chromatography-tandem mass spectrometry.<jats:italic>Results<\/jats:italic>. There were six differently expressed peptides (<jats:italic>m\/z<\/jats:italic>1305.2, 1743.9, 2184.9, 2756.1, 3223.2, and 6196.1) between the two groups of subjects, and they were identified as fragments of isoform 1 of fibrinogen alpha chain precursor, prothrombin precursor, and interalpha-trypsin inhibitor heavy chain H4. The diagnostic efficacy of<jats:italic>m\/z<\/jats:italic>2756.1 and<jats:italic>m\/z<\/jats:italic>3223.2 was better than the other peptides. Area under ROC of the<jats:italic>m\/z<\/jats:italic>2756.1, and<jats:italic>m\/z<\/jats:italic>3223.2 was 0.98 and 0.93, respectively.<jats:italic>Conclusions<\/jats:italic>. These urinary peptides are potential urinary biomarkers for monitoring of type 2 diabetic patients with CAD.<\/jats:p>","DOI":"10.1155\/2015\/758402","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T21:46:13Z","timestamp":1431985573000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Guangzhen","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking University Ninth School of Clinical Medicine, Beijing Shijitan Hospital, Beijing 100038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Capital Medical University, Beijing Shijitan Hospital, Beijing 100038, 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