{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:28:37Z","timestamp":1773923317309,"version":"3.50.1"},"reference-count":5,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Transplantation"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Acute sickle hepatic crisis (ASHC) has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS) sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepatomegaly, and mild to moderate elevations in serum AST, ALT, and bilirubin. We describe the case of a patient with a history of hemoglobin SC disease and cirrhosis caused by hepatitis C presenting approximately 1 year after liver transplantation with an ASHC. The diagnosis was confirmed by liver biopsy. Our patient was treated with RBC exchange transfusions, IV hydration, and analgesia and made a complete recovery. Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease.<\/jats:p>","DOI":"10.1155\/2015\/761740","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T21:03:08Z","timestamp":1424379788000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"J. H.","family":"Gillis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN 38104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Satapathy","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38104, USA"},{"name":"Methodist University Hospital Transplant Institute, Memphis, TN 38104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Parsa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN 38104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. B.","family":"Sylvestre","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38104, USA"},{"name":"Methodist University Hospital Transplant Institute, Memphis, TN 38104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dbouk","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38104, USA"},{"name":"Methodist University Hospital Transplant Institute, Memphis, TN 38104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24114"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-542076"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1823"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22742"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0b013e3181e8a6b3"}],"container-title":["Case Reports in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crit\/2015\/761740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crit\/2015\/761740.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crit\/2015\/761740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T22:21:41Z","timestamp":1469658101000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crit\/2015\/761740\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":5,"alternative-id":["761740","761740"],"URL":"https:\/\/doi.org\/10.1155\/2015\/761740","relation":{},"ISSN":["2090-6943","2090-6951"],"issn-type":[{"value":"2090-6943","type":"print"},{"value":"2090-6951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}