{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:09:52Z","timestamp":1761235792904},"reference-count":18,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"Objective.<\/jats:italic>To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL\/P) risk.Methods.<\/jats:italic>Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results.Results.<\/jats:italic>Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL\/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL\/P (C versus T: OR = 1.52, 95% CI = 1.28\u20131.82,P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>,I<\/mml:mi><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msup>=<\/mml:mo>0<\/mml:mn><\/mml:math>%; CC versus TT: OR = 2.58, 95% CI = 1.74\u20133.82,P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>,I<\/mml:mi><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msup>=<\/mml:mo>0<\/mml:mn><\/mml:math>%; TC + CC versus TT: OR = 1.45, 95% CI = 1.14\u20131.84,P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>,I<\/mml:mi><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msup>=<\/mml:mo>0<\/mml:mn><\/mml:math>%; CC versus TT + TC: OR=2.46, 95% CI = 1.46\u20134.14,P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>,I<\/mml:mi><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msup>=<\/mml:mo>47.0<\/mml:mn><\/mml:math>%). On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50\u20130.96,P<\/mml:mi>=<\/mml:mo>0.03<\/mml:mn><\/mml:math>,I<\/mml:mi><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msup>=<\/mml:mo>68.5<\/mml:mn><\/mml:math>%; TC versus TT: OR = 0.52, 95% CI = 0.40\u20130.68,P<\/mml:mi><<\/mml:mo>0.01<\/mml:mn><\/mml:math>,I<\/mml:mi><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msup>=<\/mml:mo>0<\/mml:mn><\/mml:math>%; TC + CC versus TT: OR = 0.52, 95% CI = 0.35\u20130.78,P<\/mml:mi><<\/mml:mo>0.010<\/mml:mn><\/mml:math>,I<\/mml:mi><\/mml:mrow>2<\/mml:mn><\/mml:mrow><\/mml:msup>=<\/mml:mo>54.4<\/mml:mn><\/mml:math>%).Conclusion<\/jats:italic>. This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL\/P based on ethnicity diversity.<\/jats:p>","DOI":"10.1155\/2015\/763090","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T22:29:17Z","timestamp":1421101757000},"page":"1-7","source":"Crossref","is-referenced-by-count":16,"title":["Association between BMP4 rs17563 Polymorphism and NSCL\/P Risk: A Meta-Analysis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yuan-Yuan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China"},{"name":"Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Qi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo-Hong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ming","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000322486"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20607"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt262"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12114"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512440578"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1617"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-9969(99)00118-1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01676"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2003.710304.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.1096"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2008.0777"},{"issue":"8","key":"13","first-page":"897","volume":"38","year":"2012","journal-title":"Jiangsu Medical Journal"},{"issue":"2","key":"14","first-page":"82","volume":"21","year":"2013","journal-title":"Beijing Journal of Stomatology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/247104"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1597\/12-048"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.10.010"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00484.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s100380050113"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2015\/763090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2015\/763090.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2015\/763090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T19:59:39Z","timestamp":1469649579000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2015\/763090\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":18,"alternative-id":["763090","763090"],"URL":"https:\/\/doi.org\/10.1155\/2015\/763090","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}