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Fat and fat-free mass were assessed by dual-energy X-ray absorptiometry. Family history of type 2 diabetes (FHDM) was reported. We determined the optimal cutoff of HOMA-IR to diagnose MetS (IDF criteria) using ROC analysis. IR was defined as HOMA-IR values above the cutoff. We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses.<jats:italic>Results.<\/jats:italic>Of the participants, 16% were obese and 9.4 % met criteria for MetS. The optimal cutoff for MetS diagnosis was a HOMA-IR value of 2.6. Based on this value, 16.3% of participants had IR. Adolescents with IR had a significantly higher prevalence of obesity, abdominal obesity, fasting hyperglycemia, and MetS compared to those who were not IR. FHDM, sarcopenia, obesity, and low adiponectin significantly increased the risk of IR.<jats:italic>Conclusions.<\/jats:italic>In adolescents, HOMA-IR \u2265 2.6 was associated with greater cardiometabolic risk.<\/jats:p>","DOI":"10.1155\/2015\/783296","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T21:03:34Z","timestamp":1438031014000},"page":"1-8","source":"Crossref","is-referenced-by-count":65,"title":["Healthy Chilean Adolescents with HOMA-IR<b>\u2265<\/b>2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors"],"prefix":"10.1155","volume":"2015","author":[{"given":"R.","family":"Burrows","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Food Technology, University of Chile, Avenida El L\u00edbano 5524, Macul, 7840390 Santiago, 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