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Macrophages are key cells in controlling histoplasmosis, a fungal infection caused by<jats:italic>Histoplasma capsulatum<\/jats:italic>(<jats:italic>Hc<\/jats:italic>). Considering that little is known about EPO\u2019s role during fungal infections and its capacity to activate macrophages, in this study we investigated the impact of EPO pretreatment on the alveolar immune response during<jats:italic>Hc<\/jats:italic>infection. The consequence of EPO pretreatment on fungal infection was determined by evaluating animal survival, fungal burden, activation of bronchoalveolar macrophages, inflammatory mediator release, and lung inflammation. Pretreatment with EPO diminished mononuclear cell numbers, increased the recruitment of F4\/80<jats:sup>+<\/jats:sup>\/CD80<jats:sup>+<\/jats:sup>and F4\/80<jats:sup>+<\/jats:sup>\/CD86<jats:sup>+<\/jats:sup>cells to the bronchoalveolar space, induced higher production of IFN\u2010<jats:italic>\u03b3<\/jats:italic>, IL\u20106, MIP\u20101<jats:italic>\u03b1<\/jats:italic>, MCP\u20101, and LTB<jats:sub>4<\/jats:sub>, reduced PGE<jats:sub>2<\/jats:sub>concentration, and did not affect fungal burden. As a consequence, we observed an increase in lung inflammation with extensive tissue damage that might account for augmented mouse mortality after infection. Our results demonstrate for the first time that EPO treatment has a deleterious impact on lung immune responses during fungal infection.<\/jats:p>","DOI":"10.1155\/2015\/786319","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T23:17:17Z","timestamp":1444691837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Erythropoietin Exacerbates Inflammation and Increases the Mortality of<i>Histoplasma capsulatum<\/i>\u2010Infected Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Gisele Aparecida","family":"Locachevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Aparecida 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