{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:53:38Z","timestamp":1791150818409,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK2011133"],"award-info":[{"award-number":["BK2011133"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Protein phosphatase 2A (PP2A), a family of the major serine\/threonine phosphatases in cells, regulates many aspects of physiological processes. However, isoform-specific substrates and the biological role of each specific member of the PP2A family remain largely unknown. In this study, we investigated whether PP2A catalytic subunit C<jats:italic>\u03b1<\/jats:italic>(PP2Ac<jats:italic>\u03b1<\/jats:italic>) is involved in chronic hepatic injury and fibrosis. A hepatocyte-specific PP2Ac<jats:italic>\u03b1<\/jats:italic>ablation mice model was established to examine the effect of PP2Ac<jats:italic>\u03b1<\/jats:italic>on carbon tetrachloride- (CCl4-) induced chronic hepatic injury and fibrosis. Our results showed that PP2Ac<jats:italic>\u03b1<\/jats:italic>knockout mice were less susceptible to chronic CCl4-induced liver injury as evidenced by lower levels of serum alanine aminotransferase and aspartate aminotransferase, decreased hepatocyte proliferation, and increased rate of apoptotic removal of the injured hepatocytes. PP2Ac<jats:italic>\u03b1<\/jats:italic>knockout mice also displayed a lesser extent of liver fibrosis as a significant decrease in the proportion of<jats:italic>\u03b1<\/jats:italic>-smooth muscle actin-expressing cells and collagen deposition was observed in their liver tissues. Furthermore, the levels of serum TGF-<jats:italic>\u03b2<\/jats:italic>1 and hepatocytic Smad phosphorylation were reduced in the PP2Ac<jats:italic>\u03b1<\/jats:italic>knockout mice. These data suggest that hepatocyte-specific ablation of PP2Ac<jats:italic>\u03b1<\/jats:italic>protects against CCl4-induced chronic hepatic injury and fibrogenesis and the protective effect is mediated at least partially through the impaired TGF-<jats:italic>\u03b2<\/jats:italic>1\/Smad signaling.<\/jats:p>","DOI":"10.1155\/2015\/794862","type":"journal-article","created":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T16:03:52Z","timestamp":1422806632000},"page":"1-10","source":"Crossref","is-referenced-by-count":21,"title":["Hepatocyte-Specific Ablation of PP2A Catalytic Subunit<i>\u03b1<\/i>Attenuates Liver Fibrosis Progression via TGF-<i>\u03b2<\/i>1\/Smad Signaling"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-2980","authenticated-orcid":true,"given":"Na","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu 210029, 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