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This study was performed to determine whether IL-37 was elevated in patients with rheumatoid arthritis (RA) and investigate the correlation between IL-37 level and disease activity and the concentration of Th1\/Th2\/Th17-related cytokines. Clinical parameters of disease activity, including the 28-joint disease activity score (DAS28) and C-reactive protein (CRP), were collected in 34 RA patients and 34 age- and sex-matched healthy controls. Plasma IL-37 was measured by ELISA. Plasma levels of TNF-<jats:italic>\u03b1<\/jats:italic>, IL-1<jats:italic>\u03b2<\/jats:italic>, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, G-CSF, GM-CSF, IFN-<jats:italic>\u03b3<\/jats:italic>, MCP-1, and MIP-1<jats:italic>\u03b2<\/jats:italic>were analyzed using the Bio-Plex suspension array system. It was found that IL-37 levels were elevated markedly in RA patients and almost undetectable in healthy controls. In addition, IL-37 levels in patients with active RA were significantly enhanced as compared with those in patients of remission. More importantly, IL-37 showed a significant correlation with disease activity (DAS28) and IL-4, IL-7, IL-10, IL-12, and IL-13 concentrations in RA patients. These findings suggest that IL-37 plays an important role in the pathogenesis of RA and may prove to be a potential biomarker of active RA.<\/jats:p>","DOI":"10.1155\/2015\/795043","type":"journal-article","created":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T21:03:38Z","timestamp":1441573418000},"page":"1-6","source":"Crossref","is-referenced-by-count":44,"title":["Plasma Interleukin-37 Is Elevated in Patients with Rheumatoid Arthritis: Its Correlation with Disease Activity and Th1\/Th2\/Th17-Related Cytokines"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ting","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-feng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, 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