{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:06Z","timestamp":1787017686821,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . To investigate blood pressure and heart rate variability in patients with primary open-angle glaucoma (POAG) to detect disturbed blood pressure regulation.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Thirty-one patients with POAG (mean age 68 \u00b1 10 years) and 48 control subjects (mean age 66 \u00b1 10 years) were included in a prospective study. Continuous blood pressure and heart rate were simultaneously and noninvasively recorded over 30\u2009min (Glaucoscreen, aviant GmbH, Jena, Germany). Data were analyzed calculating univariate linear (time domain and frequency domain), nonlinear (Symbolic Dynamics, SD) and bivariate (Joint Symbolic Dynamics, JSD) indices.\n                    <jats:italic>Results<\/jats:italic>\n                    . Using nonlinear methods, glaucoma patients were separated with more parameters compared to linear methods. In POAG, nonlinear univariate indices (pW113 and pW120_Sys) were increased while the indices pTH10_Sys and pTH11_Sys reflect a reduction of dominant patterns. Bivariate indices (JSDdia29, JSDdia50, and JSDdia52; coupling between heart rate and diastolic blood pressure) were increased in POAG. The optimum set consisting of six parameters (JSDdia29, JSDdia58, pTH9_Sys, pW231, pW110_Sys and pW120_Sys) revealed a sensitivity of 83.3% and specificity of 80.6%.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Nonlinear uni- and bivariate indices of continuous recordings of blood pressure and heart rate are altered in glaucoma. Abnormal blood pressure variability suggests disturbed autonomic regulation in patients with glaucoma.\n                  <\/jats:p>","DOI":"10.1155\/2015\/798958","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T17:19:31Z","timestamp":1443719971000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma"],"prefix":"10.1155","volume":"2015","author":[{"given":"Eva Charlotte","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, RWTH Aachen University, Pauwelsstra\u00dfe 30, 52072 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Staab","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, RWTH Aachen University, Pauwelsstra\u00dfe 30, 52072 Aachen, 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