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ADAMTS\u20107 is a member of ADAMTS family and plays a crucial role in the pathogenesis of arthritis. Overexpression of ADAMTS\u20107 gene promotes the breakdown of cartilage oligomeric matrix protein (COMP) matrix and accelerates the progression of both surgically induced osteoarthritis and collagen\u2010induced arthritis. Moreover, ADAMTS\u20107 and tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) form a positive feedback loop in osteoarthritis. More significantly, granulin\u2010epithelin precursor, a growth factor has important roles in bone development and bone\u2010associated diseases, disturbs the interaction between ADAMTS\u20107 and COMP, and prevents COMP degradation. This review is based on our results and provides an overview of current knowledge of ADAMTS\u20107, including its structure, function, gene regulation, and inflammatory diseases involvement.\n                  <\/jats:p>","DOI":"10.1155\/2015\/801546","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T16:45:21Z","timestamp":1448901921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Function and Roles of ADAMTS\u20107 in Inflammatory 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