{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:49:53Z","timestamp":1740152993018,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30870952","201015176","20140413016GH","2014109"],"award-info":[{"award-number":["30870952","201015176","20140413016GH","2014109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["30870952","201015176","20140413016GH","2014109"],"award-info":[{"award-number":["30870952","201015176","20140413016GH","2014109"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin Provincial Science & Technology Department","award":["30870952","201015176","20140413016GH","2014109"],"award-info":[{"award-number":["30870952","201015176","20140413016GH","2014109"]}]},{"name":"Graduate Innovation Fund of Jilin University","award":["30870952","201015176","20140413016GH","2014109"],"award-info":[{"award-number":["30870952","201015176","20140413016GH","2014109"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The incidence rate of papillary thyroid cancer (PTC) has increased over the past decades, but the pathogenesis remains unclear. rs2910164, located in pre-miR-146a, has been studied in PTCs with different ethnicity, but the results were inconsistent. Here we evaluate the association between rs2910164 polymorphism and PTC and investigate the effect of this polymorphism on patients\u2019 clinicopathological characteristics. 1238 PTC patients and 1275 controls, all Han population, from Northern China, were included in our study. rs2910164 was genotyped using Matrix-Assisted Laser Desorption\/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS). Analysis of inheritance model was performed using the SNPStats program. Strength of association was assessed by odds ratio (OR) and 95% confidence interval (CI). Overall, no statistical difference in rs2910164 genotype distribution and allelic frequencies between cases and controls was found, and patients with different genotypes had similar clinicopathological characteristics in terms of stage, location, concurrent of benign thyroid tumor, and thyroiditis, while, as the number of G alleles increased, proportion of patients aged \u226545 years and those without metastasis increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msub><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>trend<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>trend<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.003<\/mml:mn><\/mml:math>, resp.). However, no association remained significant after Bonferroni correction under any model of inheritance. Our results suggest no association between rs2910164 polymorphism with PTC and patients\u2019 clinicopathological characteristics.<\/jats:p>","DOI":"10.1155\/2015\/802562","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T16:04:28Z","timestamp":1447862668000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer"],"prefix":"10.1155","volume":"2015","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China"},{"name":"Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China"},{"name":"Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Sam","family":"Kanu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and 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