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In 10\u201350% of adults with persistent pruritus, it can be an important dermatologic clue for the presence of a significant underlying systemic disease such as renal insufficiency, cholestasis, hematologic disorder, or malignancy (Etter and Myers, 2002; Zirwas and Seraly, 2001). This review describes the presence of pruritus in different systemic diseases. It is quite important to discover the cause of pruritus for providing relief for the patients experiencing substantial morbidity caused by this condition.<\/jats:p>","DOI":"10.1155\/2015\/803752","type":"journal-article","created":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T23:28:51Z","timestamp":1436484531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Pruritus in Systemic Diseases: A Review of Etiological Factors and New Treatment Modalities"],"prefix":"10.1155","volume":"2015","author":[{"given":"Nagihan","family":"Tarikci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emek","family":"Kocat\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eule","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilteri\u015f","family":"O\u011fuz Topal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"\u00dclk\u00fcmen Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralfi","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0195-5616(88)50101-8"},{"key":"e_1_2_10_2_2","first-page":"67","article-title":"Pruritus in certain internal diseases","volume":"11","author":"Yonova D.","year":"2007","journal-title":"Hippokratia"},{"key":"e_1_2_10_3_2","first-page":"495","article-title":"Itch: a symptom of occult disease","volume":"33","author":"Navaz H.","year":"2004","journal-title":"Australian Family Physician"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.03.010"},{"key":"e_1_2_10_5_2","first-page":"161","article-title":"Uremic pruritus in chronic hemodialysis patients","volume":"21","author":"Narita I.","year":"2008","journal-title":"Journal of Nephrology"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.003"},{"key":"e_1_2_10_7_2","first-page":"91","article-title":"Uremic pruritus pathogenesis, revisited","volume":"7","author":"Attia E. 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