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With the aim of developing an active immunogenic vaccine without need of coadjuvant modification for human trials and therefore avoiding such side effects, we designed the A<jats:italic>\u03b2<\/jats:italic><jats:sub>1\u201342<\/jats:sub>vaccine (EB101), delivered in a liposomal matrix, that based on our previous studies significantly prevents and reverses the AD neuropathology, clearing A<jats:italic>\u03b2<\/jats:italic>plaques while markedly reducing neuronal degeneration, behavioral deficits, and minimizing neuroinflammation in APP\/PS1 transgenic mice. Here, the efficacy of our immunogenic vaccine EB101 was compared with the original immunization vaccine cocktail A<jats:italic>\u03b2<\/jats:italic><jats:sub>42<\/jats:sub>+ CFA\/IFA (Freund\u2019s adjuvant), in order to characterize the effect of sphingosine-1-phosphate (S1P) in the immunotherapeutic response. Quantitative analysis of amyloid burden showed a notable decrease in the neuroinflammation reaction against A<jats:italic>\u03b2<\/jats:italic>plaques when S1P was compared with other treatments, suggesting that S1P plays a key role as a neuroprotective agent. Moreover, EB101 immunized mice presented a protective immunogenic reaction resulting in the increase of A<jats:italic>\u03b2<\/jats:italic>-specific antibody response and decrease of reactive glia in the affected brain areas, leading to a Th2 immunological reaction.<\/jats:p>","DOI":"10.1155\/2015\/807146","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T16:11:01Z","timestamp":1423671061000},"page":"1-16","source":"Crossref","is-referenced-by-count":15,"title":["A Comparative Evaluation of a Novel Vaccine in APP\/PS1 Mouse Models of Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Iv\u00e1n","family":"Carrera","sequence":"first","affiliation":[{"name":"Department of Neuroscience, EuroEspes Biotechnology, Poligono de Bergondo, Nave F, 15165 A Coru\u00f1a, 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