{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:41:21Z","timestamp":1790682081523,"version":"4.1.0"},"reference-count":51,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Inflammation, together with related oxidative stress, is linked with the etiology of kwashiorkor, a form of severe acute malnutrition in children. A diet rich in anti-inflammatory and antioxidant phytochemicals may offer potential for the prevention and treatment of kwashiorkor. We selected and assayed five leafy green vegetables, two wild fruits, and six medicinal plants from Kenya for their antioxidant and anti-inflammatory properties. Consensus regarding medicinal plant use was established from ethnobotanical data.<jats:italic>Methods<\/jats:italic>. Antioxidant activity and phenolic content were determined using the oxygen radical absorbance capacity (ORAC) assay and Folin-Ciocalteu procedure, respectively. Anti-inflammatory activity was assessed<jats:italic>in vitro<\/jats:italic>targeting the inflammatory mediator tumour necrosis factor-alpha (TNF-<jats:italic>\u03b1<\/jats:italic>).<jats:italic>Results. Mangifera indica<\/jats:italic>(leaves used medicinally) showed the greatest antioxidant activity (5940 \u00b1 632\u2009<jats:italic>\u00b5<\/jats:italic>M TE\/<jats:italic>\u00b5<\/jats:italic>g) and total phenolic content (337 \u00b1 3\u2009mg\u2009GAE\/g) but<jats:italic>Amaranthus dubius<\/jats:italic>(leafy vegetable) showed the greatest inhibition of TNF-<jats:italic>\u03b1<\/jats:italic>(IC<jats:sub>50<\/jats:sub>= 9 \u00b1 1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL), followed by<jats:italic>Ocimum americanum<\/jats:italic>(medicinal plant) (IC<jats:sub>50<\/jats:sub>= 16 \u00b1 1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL). Informant consensus was significantly correlated with anti-inflammatory effects among active medicinal plants (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msup><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn>0.7639<\/mml:mn><mml:mo>,<\/mml:mo><mml:mo>\u2009<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0228<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Several plant species commonly consumed by Kenyan children possess activity profiles relevant to the prevention and treatment of kwashiorkor and warrant further investigation.<\/jats:p>","DOI":"10.1155\/2015\/807158","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T21:04:40Z","timestamp":1436389480000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["Antioxidant and Anti-Inflammatory Activities of Kenyan Leafy Green Vegetables, Wild Fruits, and Medicinal Plants with Potential Relevance for Kwashiorkor"],"prefix":"10.1155","volume":"2015","author":[{"given":"H. R.","family":"Tufts","sequence":"first","affiliation":[{"name":"Centre for Indigenous Peoples\u2019 Nutrition and Environment, School of Dietetics and Human Nutrition, McGill University, Sainte-Anne-de-Bellevue, QC, Canada H9X 3V9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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