{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T12:19:48Z","timestamp":1769948388483,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Northeast Biotechnology Network\/State University of Cear\u00e1"},{"name":"Regional University of Cariri, CE\/Microbiology Laboratory and Molecular Biology"},{"name":"Laboratory of Natural Products, State University of Cear\u00e1"},{"name":"Technology Development Park"},{"name":"Faculty of Juazeiro do Norte, Cear\u00e1 State"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The high incidence of fungal infections has led to the continuous search for new drugs. Extracts of<jats:italic>Luehea paniculata<\/jats:italic>, a tree of multiple medicinal uses, were evaluated for anti-<jats:italic>Candida<\/jats:italic>activity, as well as its modulator potential of the Fluconazole antibiotic. Chemical prospecting of ethanol extracts of leaf and bark was carried out, the quantification of total phenols and flavonoids, characterized by the HPLC-DAD technique. The rosmarinic acid and the vitexin flavonoid were observed as major constituents in ELELP and ESWELP, respectively. Antioxidant activity was also evaluated by the method of scavenging the free radical DPPH, and quercetin was used as standard, obtaining IC<jats:sub>50<\/jats:sub>values: 0.341 (mg\/mL) for ELELP and 0.235 (mg\/mL) for ESWELP. The microdilution assay was performed for antifungal activity against strains of<jats:italic>Candida albicans, C. krusei<\/jats:italic>, and<jats:italic>C. tropicalis<\/jats:italic>and showed minimum inhibitory concentrations values \u22651024\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. In the modulator action of extracts on Fluconazole against multiresistant clinical isolates of<jats:italic>Candida<\/jats:italic>(subinhibitory concentration minimum of 128\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL), a significant synergism was observed, indicating that the extracts potentiated the antifungal effect against<jats:italic>C. tropicalis<\/jats:italic>, where antioxidant flavonoids could be responsible. This is the first report about modifying activity of the antibiotic action of a species of the genus<jats:italic>Luehea<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2015\/807670","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T21:03:11Z","timestamp":1424120591000},"page":"1-10","source":"Crossref","is-referenced-by-count":14,"title":["Phytochemical Analysis and Modulation of Antibiotic Activity by<i>Luehea paniculata<\/i>Mart. &amp; Zucc. 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