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Natalizumab is highly effective, resulting in significant decreases in rates of both relapse and disability accumulation, as well as marked decrease in MRI evidence of disease activity. As such, utilization of natalizumab is increasing, and the presentation of its associated complications is increasing accordingly. This review focuses on the clinical and neuroimaging features of the major complications associated with natalizumab therapy, focusing on the rare but devastating progressive multifocal leukoencephalopathy (PML). Associated entities including PML associated immune reconstitution inflammatory syndrome (PML-IRIS) and the emerging phenomenon of rebound of MS disease activity after natalizumab discontinuation are also discussed. Early recognition of neuroimaging features associated with these processes is critical in order to facilitate prompt diagnosis, treatment, and\/or modification of therapies to improve patient outcomes.<\/jats:p>","DOI":"10.1155\/2015\/809252","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T21:03:06Z","timestamp":1442869386000},"page":"1-14","source":"Crossref","is-referenced-by-count":21,"title":["Neuroimaging of Natalizumab Complications in Multiple Sclerosis: PML and Other Associated Entities"],"prefix":"10.1155","volume":"2015","author":[{"given":"Justin M.","family":"Honce","sequence":"first","affiliation":[{"name":"Division of Neuroradiology, University of Colorado School of Medicine, 12700 E 19th Avenue Mail Stop C278, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Nagae","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, University of Colorado School of 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