{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:11:59Z","timestamp":1790795519726,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Zhejiang Provincial Traditional Chinese Medicine Science and Technology Plan","award":["2006C095"],"award-info":[{"award-number":["2006C095"]}]},{"name":"Zhejiang Provincial Traditional Chinese Medicine Science and Technology Plan","award":["89212012"],"award-info":[{"award-number":["89212012"]}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["2006C095"],"award-info":[{"award-number":["2006C095"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["89212012"],"award-info":[{"award-number":["89212012"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>To study the role of adenosine A2A receptor (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>2A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>) in mediating the anti-inflammatory effect of electroacupuncture (EA) on synovitis in collagen-induced arthritis (CIA), C57BL\/6 mice were divided into five treatment groups:<jats:italic>Sham-control, CIA-control, CIA-EA, CIA-SCH58261<\/jats:italic>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>2A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>antagonist), and<jats:italic>CIA-EA-SCH58261<\/jats:italic>. All mice except those in the<jats:italic>Sham-control<\/jats:italic>group were immunized with collagen II for arthritis induction. EA treatment was administered using the stomach 36 and spleen 6 points, and stimulated with a continuous rectangular wave for 30\u2009min daily. EA treatment and SCH58261 were administered daily from days 35 to 49 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:math>). After treatment, X-ray radiography of joint bone morphology was established at day 60 and mouse blood was collected for ELISA determination of tumor necrosis factor alpha (TNF-<jats:italic>\u03b1<\/jats:italic>) levels. Mice were sacrificed and processed for histological examination of pathological changes of joint tissue, including hematoxylin-eosin staining and immunohistochemistry of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>2A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>expression. EA treatment resulted in significantly reduced pathological scores, TNF-<jats:italic>\u03b1<\/jats:italic>concentrations, and bone damage X-ray scores. Importantly, the anti-inflammatory and tissue-protective effect of EA treatment was reversed by coadministration of SCH58261. Thus, EA treatment exerts an anti-inflammatory effect resulting in significant protection of cartilage by activation of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:msub><mml:mrow><mml:mtext>A<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>2A<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mtext>R<\/mml:mtext><\/mml:math>in the synovial tissue of CIA.<\/jats:p>","DOI":"10.1155\/2015\/809560","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T16:02:59Z","timestamp":1424102579000},"page":"1-11","source":"Crossref","is-referenced-by-count":8,"title":["Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Qi-hui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Acupuncture, The First Affiliated Hospital of WenZhou Medical University, Wenzhou, Zhejiang 325000, 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University, Wenzhou, Zhejiang 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-jie","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The First Affiliated Hospital of WenZhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The First Affiliated Hospital of WenZhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-shen","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, The First Affiliated Hospital of WenZhou Medical University, Wenzhou, Zhejiang 325000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Fan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston 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