{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:31:42Z","timestamp":1789079502745,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES021800"],"award-info":[{"award-number":["R01 ES021800"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AA022146"],"award-info":[{"award-number":["R01 AA022146"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES021800"],"award-info":[{"award-number":["R01 ES021800"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AA022146"],"award-info":[{"award-number":["R01 AA022146"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Epidemiological studies indicate exposures to the herbicide paraquat (PQ) and fungicide maneb (MB) are associated with increased risk of Parkinson\u2019s disease (PD). Oxidative stress appears to be a premier mechanism that underlies damage to the nigrostriatal dopamine system in PD and pesticide exposure. Enhanced oxidative stress leads to lipid peroxidation and production of reactive aldehydes; therefore, we conducted proteomic analyses to identify carbonylated proteins in the striatum and cortex of pesticide-treated mice in order to elucidate possible mechanisms of toxicity. Male C57BL\/6J mice were treated biweekly for 6 weeks with saline, PQ (10\u2009mg\/kg), MB (30\u2009mg\/kg), or the combination of PQ and MB (PQMB). Treatments resulted in significant behavioral alterations in all treated mice and depleted striatal dopamine in PQMB mice. Distinct differences in 4-hydroxynonenal-modified proteins were observed in the striatum and cortex. Proteomic analyses identified carbonylated proteins and peptides from the cortex and striatum, and pathway analyses revealed significant enrichment in a variety of KEGG pathways. Further analysis showed enrichment in proteins of the actin cytoskeleton in treated samples, but not in saline controls. These data indicate that treatment-related effects on cytoskeletal proteins could alter proper synaptic function, thereby resulting in impaired neuronal function and even neurodegeneration.<\/jats:p>","DOI":"10.1155\/2015\/812532","type":"journal-article","created":{"date-parts":[[2015,8,9]],"date-time":"2015-08-09T17:05:55Z","timestamp":1439139955000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Christina","family":"Coughlan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas I.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Lohr","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Medicine, Rutgers University Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Michael","family":"Caudle","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer S.","family":"Fritz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Roede","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800277"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.2001.4264"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-8-6"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.02.008"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9574-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.03.031"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079x.2010.00819.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(00)02496-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02781.x"},{"issue":"24","key":"11","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.1523\/JNEUROSCI.20-24-09207.2000","volume":"20","year":"2000","journal-title":"Journal of Neuroscience"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.09.004"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-013-1005-4"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0176-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.01.060"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr058"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.04.007"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1865"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440712"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087753"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2696"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(91)90192-6"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1021\/tx025590o"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-2797(02)00178-3"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1021\/tx800244u"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1021\/tx100355a"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.10.694"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.06.002"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038459"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.06.026"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-49"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.04.025"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0319-07.2007"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.12.013"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.08.032"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1021\/tx300002q"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1495-09.2009"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-813x(02)00092-x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(07)70327-7"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0319"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870170065015"},{"key":"44","first-page":"262","volume":"45c","year":"2014","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25829"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-14-142"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/450939"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.05.013"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.14-10"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4312"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00283.2008"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.04.004"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m109.019927"},{"issue":"11","key":"54","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1523\/JNEUROSCI.22-11-04399.2002","volume":"22","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(00)00563-x"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m103947200"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m209042200"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.4161\/cam.24803"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.09.011"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(00)00123-9"},{"issue":"3","key":"61","first-page":"22","volume":"1","year":"2013","journal-title":"OA Anatomy"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.07.012"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/s1537-1891(02)00200-8"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm223"},{"issue":"1","key":"65","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/toxsci\/kfn028","volume":"103","year":"2008","journal-title":"Toxicological Sciences"}],"container-title":["Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/812532.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/812532.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/812532.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T01:36:06Z","timestamp":1567042566000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/pd\/2015\/812532\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":65,"alternative-id":["812532","812532"],"URL":"https:\/\/doi.org\/10.1155\/2015\/812532","relation":{},"ISSN":["2090-8083","2042-0080"],"issn-type":[{"value":"2090-8083","type":"print"},{"value":"2042-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}