{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:02:10Z","timestamp":1770537730744,"version":"3.49.0"},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>BACKGROUND: Severe alcoholic hepatitis (AH) is associated with a substantial risk for short-term mortality.<\/jats:p><jats:p>OBJECTIVES: To identify prognostic factors and validate well-known prognostic models in a Canadian population of patients hospitalized for AH.<\/jats:p><jats:p>METHODS: In the present retrospective study, patients hospitalized for AH in Calgary, Alberta, between January 2008 and August 2012 were included. Stepwise logistic regression models identified independent risk factors for 90-day mortality, and the discrimination of prognostic models (Model for End-stage Liver Disease [MELD] and Maddrey discriminant function [DF]) were examined using areas under the ROC curves.<\/jats:p><jats:p>RESULTS: A total of 122 patients with AH were hospitalized during the study period; the median age was 49 years (interquartile range [IQR] 42 to 55 years) and 60% were men. Median MELD score and Maddrey DF on admission were 21 (IQR 18 to 24) and 45 (IQR 26 to 62), respectively. Seventy-three percent of patients received corticosteroids and\/or pentoxifylline, and the 90-day mortality was 17%. Independent predictors of mortality included older age, female sex, international normalized ratio, MELD score and Maddrey DF (all P&lt;0.05). For discrimination of 90-day mortality, the areas under the ROC curves of the prognostic models (MELD 0.64; Maddrey DF 0.68) were similar (P&gt;0.05). At optimal cut-offs of \u226522 for MELD score and \u226537 for Maddrey DF, both models excluded death with high certainty (negative predictive values 90% and 96%, respectively).<\/jats:p><jats:p>CONCLUSIONS: In patients hospitalized for AH, well-known prognostic models can be used to predict 90-day mortality, particularly to identify patients with a low risk for death.<\/jats:p>","DOI":"10.1155\/2015\/814827","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:05:12Z","timestamp":1458029112000},"page":"131-138","source":"Crossref","is-referenced-by-count":23,"title":["Risk Factors for Mortality in Patients with Alcoholic Hepatitis and Assessment of Prognostic Models: A Population-Based Study"],"prefix":"10.1155","volume":"29","author":[{"given":"Jack XQ","family":"Pang","sequence":"first","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Ross","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith A","family":"Borman","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Medical Services, Alberta Health Services, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilaad G","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J","family":"Heitman","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G","family":"Swain","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Burak","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hude","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P","family":"Myers","sequence":"additional","affiliation":[{"name":"Liver Unit, Division of Gastroenterology and Hepatology, Calgary, Alberta, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2015\/814827.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2015\/814827.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T15:38:11Z","timestamp":1471966691000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2015\/814827\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"alternative-id":["814827"],"URL":"https:\/\/doi.org\/10.1155\/2015\/814827","relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}