{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:52:23Z","timestamp":1792799543740,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["808242"],"award-info":[{"award-number":["808242"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["2010-77"],"award-info":[{"award-number":["2010-77"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Foundation of Department of Health of Hainan Province, China","award":["808242"],"award-info":[{"award-number":["808242"]}],"id":[{"id":"https:\/\/ror.org\/04nm1xm49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Scientific Research Foundation of Department of Health of Hainan Province, China","award":["2010-77"],"award-info":[{"award-number":["2010-77"]}],"id":[{"id":"https:\/\/ror.org\/04nm1xm49","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Pretreatment with the angiotensin\u2010converting inhibitor captopril or volatile anesthetic isoflurane has, respectively, been shown to attenuate myocardial ischemia reperfusion (MI\/R) injury in rodents and in patients. It is unknown whether or not captopril pretreatment and isoflurane preconditioning (Iso) may additively or synergistically attenuate MI\/R injury.\n                    <jats:italic>Methods and Results.<\/jats:italic>\n                    Patients selected for heart valve replacement surgery were randomly assigned to five groups: untreated control (Control), captopril pretreatment for 3 days (Cap3d), or single dose captopril (Cap1hr, 1 hour) before surgery with or without Iso (Cap3d+Iso and Cap1hr+Iso). Rabbit MI\/R model was induced by occluding coronary artery for 30\u2009min followed by 2\u2010hour reperfusion. Rabbits were randomized to receive sham operation (Sham), MI\/R (I\/R), captopril (Cap, 24 hours before MI\/R), Iso, or the combination of captopril and Iso (Iso+Cap). In patients, Cap3d+Iso but not Cap1hr+Iso additively reduced postischemic myocardial injury and attenuated postischemic myocardial inflammation. In rabbits, Cap or Iso significantly reduced postischemic myocardial infarction. Iso+Cap additively reduced cellular injury that was associated with improved postischemic myocardial functional recovery and reduced myocardial apoptosis and attenuated oxidative stress.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    A joint use of 3\u2010day captopril treatment and isoflurane preconditioning additively attenuated MI\/R by reducing oxidative stress and inflammation.\n                  <\/jats:p>","DOI":"10.1155\/2015\/819232","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T17:03:00Z","timestamp":1438016580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in 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