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No biomarkers of fat mass alterations have been defined for application to the neoplastic state. Several inflammatory cytokines have been implicated in mediating fat loss associated with cachexia; however, plasma levels may not relate to adipose atrophy. Zinc\u2010<jats:italic>\u03b1<\/jats:italic>2\u2010glycoprotein may be a local catabolic mediator within adipose tissue rather than serving as a plasma biomarker of fat loss. Plasma glycerol and leptin associate with adipose tissue atrophy and mass, respectively; however, no study has evaluated their potential as a prognostic biomarker of cachexia\u2010associated fat loss. This review confirms the need for further studies to identify valid prognostic biomarkers to identify loss of fat based on changes in plasma levels of biomarkers.<\/jats:p>","DOI":"10.1155\/2015\/820934","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T21:04:11Z","timestamp":1444079051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia"],"prefix":"10.1155","volume":"2015","author":[{"given":"Maryam","family":"Ebadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera C.","family":"Mazurak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc927"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(10)70218-7"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu6115280"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23802"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-06-4585"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.11.006"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21013"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789x.2009.00623.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1079\/bjn20041213"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02474.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111.315200"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci200319246"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/spc.0b013e32834bde0e"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.10.008"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32833ed177"},{"key":"e_1_2_8_16_2","unstructured":"Dictionary of Cancer Terms National Cancer Institute http:\/\/www.Cancer.gov\/dictionary\/?searchTxt=biomarker."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.124347.111"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.1.150"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1878-5085-4-7"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.03.006"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.011"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/mco.0b013e32835f816c"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ciresp.2010.12.005"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199550197.001.0001"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.060228"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27273"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0367-z"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a121917"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2001110"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111.257923"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021687"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/316552a0"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.11.051"},{"key":"e_1_2_8_34_2","first-page":"1355","article-title":"Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients","volume":"21","author":"Karayiannakis A. 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