{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:50:34Z","timestamp":1776840634225,"version":"3.51.2"},"reference-count":10,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>We report the rare occurrence of donor-derived myeloid sarcoma in two kidney transplant patients who received organs from a single deceased donor. There was no evidence of preexisting hematologic malignancy in the donor at the time of organ recovery. Both recipients developed leukemic involvement that appeared to be limited to the transplanted organ. Fluorescence<jats:italic>in situ<\/jats:italic>hybridization (FISH) and molecular genotyping analyses confirmed that the malignant cells were of donor origin in each patient. Allograft nephrectomy and immediate withdrawal of immunosuppression were performed in both cases; systemic chemotherapy was subsequently administered to one patient. Both recipients were in remission at least one year following the diagnosis of donor-derived myeloid sarcoma. These cases suggest that restoration of the immune system after withdrawal of immunosuppressive therapy and allograft nephrectomy may be sufficient to control HLA-mismatched donor-derived myeloid sarcoma without systemic involvement.<\/jats:p>","DOI":"10.1155\/2015\/821346","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T21:08:42Z","timestamp":1429650522000},"page":"1-5","source":"Crossref","is-referenced-by-count":9,"title":["Donor-Derived Myeloid Sarcoma in Two Kidney Transplant Recipients from a Single Donor"],"prefix":"10.1155","volume":"2015","author":[{"given":"Amudha","family":"Palanisamy","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Persad","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick P.","family":"Koty","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie L.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Hematology and Oncology, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Stratta","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber M.","family":"Reeves-Daniel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan C.","family":"Farney","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Beaty","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Pettenati","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samy S.","family":"Iskandar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Grier","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Kaczmorski","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Doares","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Gautreaux","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry I.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayard L.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Hematology and Oncology, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC 27103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200202270-00017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.11.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12430"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403498"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199909093411105"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-497875"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1158\/0008-5472.375.65.2","volume":"65","year":"2005","journal-title":"Cancer Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20234"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-08-2754"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0811036"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2015\/821346.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2015\/821346.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2015\/821346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T17:31:17Z","timestamp":1691602277000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crin\/2015\/821346\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":10,"alternative-id":["821346","821346"],"URL":"https:\/\/doi.org\/10.1155\/2015\/821346","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}