{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T04:58:29Z","timestamp":1648875509199},"reference-count":30,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis. The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR). Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study. Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP). The frequencies of the heterozygote genotype (Lys\/Gln-AC) and homozygote genotype (Gln\/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.049<\/mml:mn><\/mml:math>; 38.15% versus 16.2%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.018<\/mml:mn><\/mml:math>). Homozygote variant (Gln\/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097\u20133.863;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.018<\/mml:mn><\/mml:math>). Heterozygote variant (Lys\/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041\u20132.129;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.049<\/mml:mn><\/mml:math>). The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101\u20131.992;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.011<\/mml:mn><\/mml:math>). This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.<\/jats:p>","DOI":"10.1155\/2015\/825020","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T19:01:54Z","timestamp":1446058914000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture"],"prefix":"10.1155","volume":"2015","author":[{"given":"Aysel","family":"Kalayci Yigin","sequence":"first","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Bulent Vatan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, 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