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Using the INMEX (integrative meta-analysis of expression data) program, we performed the meta-analysis to identify consistently differentially expressed (DE) genes in ankylosing spondylitis and further performed functional interpretation (gene ontology analysis and pathway analysis) of the DE genes identified in the meta-analysis. Three microarray datasets (26 cases and 29 controls in total) were collected for meta-analysis. 905 consistently DE genes were identified in ankylosing spondylitis, among which 482 genes were upregulated and 423 genes were downregulated. The upregulated gene with the smallest combined rank product (RP) was\n                    <jats:italic>GNG11<\/jats:italic>\n                    (combined\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mtext>R<\/mml:mtext>\n                      <mml:mtext>P<\/mml:mtext>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>29<\/mml:mn>\n                      <mml:mn>9.64<\/mml:mn>\n                    <\/mml:math>\n                    ). The downregulated gene with the smallest combined RP was\n                    <jats:italic>S100P<\/jats:italic>\n                    (combined\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mtext>RP<\/mml:mtext>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>335.94<\/mml:mn>\n                    <\/mml:math>\n                    ). In the gene ontology (GO) analysis, the most significantly enriched GO term was \u201cimmune system process\u201d (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>3.46<\/mml:mn>\n                      <mml:mo>\u00d7<\/mml:mo>\n                      <mml:msup>\n                        <mml:mrow>\n                          <mml:mn>10<\/mml:mn>\n                        <\/mml:mrow>\n                        <mml:mrow>\n                          <mml:mo>-<\/mml:mo>\n                          <mml:mn>26<\/mml:mn>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                    <\/mml:math>\n                    ). The most significant pathway identified in the pathway analysis was antigen processing and presentation (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>8.40<\/mml:mn>\n                      <mml:mo>\u00d7<\/mml:mo>\n                      <mml:msup>\n                        <mml:mrow>\n                          <mml:mn>10<\/mml:mn>\n                        <\/mml:mrow>\n                        <mml:mrow>\n                          <mml:mo>-<\/mml:mo>\n                          <mml:mn>5<\/mml:mn>\n                        <\/mml:mrow>\n                      <\/mml:msup>\n                    <\/mml:math>\n                    ). The consistently DE genes in ankylosing spondylitis and biological pathways associated with those DE genes identified provide valuable information for studying the pathophysiology of ankylosing spondylitis.\n                  <\/jats:p>","DOI":"10.1155\/2015\/826316","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T16:01:30Z","timestamp":1421942490000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["Identification of Potential Transcriptomic Markers in Developing Ankylosing Spondylitis: A Meta-Analysis of Gene Expression Profiles"],"prefix":"10.1155","volume":"2015","author":[{"given":"Fang","family":"Fang","sequence":"first","affiliation":[{"name":"Institute of Pediatric Research, Children\u2019s Hospital of Soochow University, Suzhou 215003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Research, Children\u2019s Hospital of Soochow University, Suzhou 215003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Research, Children\u2019s Hospital of Soochow University, Suzhou 215003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Research, Children\u2019s Hospital of Soochow University, Suzhou 215003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Research, Children\u2019s Hospital of Soochow University, Suzhou 215003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.06.006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket387"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/ar3309"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/art.23512"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt338"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl476"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl567"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.112"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4893"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4149\/av_2013_02_238"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.013904"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0b013e3181e15cc8"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/ar3857"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/ar4096"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.06.013"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2667"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/826316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/826316.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/826316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T22:30:19Z","timestamp":1471559419000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/826316\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"alternative-id":["826316","826316"],"URL":"https:\/\/doi.org\/10.1155\/2015\/826316","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}