{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:19:15Z","timestamp":1782321555902,"version":"3.54.5"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Glaucoma is the second leading cause of blindness worldwide. Although the mechanism of the development of primary open-angle glaucoma (POAG) is not fully understood, elevated intraocular pressure (IOP) is considered the most important risk factor. Several vascular factors have also been identified as risk factors and can lead to hypoperfusion of the optic nerve head and thus may play an important role in the pathogenesis and progression of POAG. The results of the present study suggest that both high and low blood pressure (BP) are associated with an increased risk of POAG based on a comprehensive literature review. Elevated BP is associated with elevated IOP, leading to increased risk of glaucoma, but excessive BP lowering in glaucoma patients may cause a drop in ocular perfusion pressure (OPP) and subsequent ischemic injury. The relationship between IOP, OPP, and BP suggests that the relationship between BP and glaucoma progression is U-shaped.<\/jats:p>","DOI":"10.1155\/2015\/827516","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T17:04:39Z","timestamp":1445187879000},"page":"1-7","source":"Crossref","is-referenced-by-count":48,"title":["The Association between Primary Open-Angle Glaucoma and Blood Pressure: Two Aspects of Hypertension and Hypotension"],"prefix":"10.1155","volume":"2015","author":[{"given":"Hye Jin","family":"Chung","sequence":"first","affiliation":[{"name":"HanGil Eye Hospital, Incheon 21388, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-4890","authenticated-orcid":true,"given":"Hyung Bin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 403-720, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 403-720, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"186","volume":"107","year":"1989","journal-title":"American Journal of Ophthalmology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470030069026"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(92)31774-9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(96)30449-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.6.701"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080080050026"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00223-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(98)00272-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.06.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s1350-9462(02)00008-3"},{"issue":"8","key":"11","first-page":"1105","volume":"26","year":"1985","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"6","key":"12","first-page":"412","volume":"6","year":"1997","journal-title":"Journal of Glaucoma"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6257(99)00046-6"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790601.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12354"},{"issue":"5","key":"16","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajo.2010.01.018","volume":"149","year":"2010","journal-title":"American Journal of Ophthalmology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(00)00138-x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0457-5"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/icu.0b013e32831eef82"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.041"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.247"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.2010.43.2.125"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0012"},{"issue":"11","key":"24","first-page":"2361","volume":"31","year":"1990","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.10.046"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.11.1631"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(02)00666-4"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000145389.15201.7f"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90414-1"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90489-X"},{"issue":"4","key":"31","first-page":"410","volume":"26","year":"1985","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.09.003"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.09.002"},{"key":"34","first-page":"735","volume-title":"Microcirculation of the ocular fundus","year":"2008"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(94)90157-0"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.05.003"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(78)92998-7"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.05.007"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/5.6.386"},{"issue":"13","key":"40","first-page":"2707","volume":"39","year":"1998","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.079285"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-14-127"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024549"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200408000-00010"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(95)31054-8"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.029"},{"issue":"12","key":"47","first-page":"1706","volume":"27","year":"1986","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12298"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031104"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.03.016"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.02.055"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.03.017"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.7.954"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2956"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100070092031"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.12.1819"},{"issue":"9","key":"57","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/ajh\/hpv016","volume":"28","year":"2015","journal-title":"American Journal of Hypertension"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199912000-00017"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2006.02.008"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.10.864"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1053"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0615"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12740"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4867"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.6.805"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/827516.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/827516.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/827516.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T17:31:44Z","timestamp":1498239104000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/827516\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":65,"alternative-id":["827516","827516"],"URL":"https:\/\/doi.org\/10.1155\/2015\/827516","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}