{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:46:16Z","timestamp":1789872376246,"version":"4.0.1"},"reference-count":23,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>The aim of the present study was to compare macular thickness in patients with keratoconus (KC) with macular thickness in healthy subjects.<jats:italic>Subjects and Methods.<\/jats:italic>Twenty-six patients with KC and 52 control subjects were included. The macular structure was evaluated using a Zeiss Cirrus HD-OCT. The scan pattern used was 512 \u00d7 128, which covers an area of approximately 6 \u00d7 6\u2009mm of the retina. The cube volume was assessed as well as macular thickness in each of the 9 sectors defined by the software.<jats:italic>Results.<\/jats:italic>The mean signal strength was significantly lower in the KC group (mean 8.4, range 6\u201310) compared with the control group (mean 9.7, range 7\u201310),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>(unpaired<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:math>-test). There were no significant differences in cube volume (unpaired<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:math>-test), cube average thickness, or macular thickness between the KC group and the control subjects in any of the retinal locations (one-way ANOVA).<jats:italic>Conclusion.<\/jats:italic>Macular structure as measured by OCT in KC subjects should be expected to lie within the range of age and sex matched controls.<\/jats:p>","DOI":"10.1155\/2015\/832863","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T16:12:58Z","timestamp":1433952778000},"page":"1-5","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of Macular Thickness in Patients with Keratoconus and Control Subjects Using the Cirrus HD-OCT"],"prefix":"10.1155","volume":"2015","author":[{"given":"R. L.","family":"Brautaset","sequence":"first","affiliation":[{"name":"Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, P.O. Box 8056, 10420 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ros\u00e9n","sequence":"additional","affiliation":[{"name":"Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, P.O. Box 8056, 10420 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cervi\u00f1o","sequence":"additional","affiliation":[{"name":"Optics Department, University of Valencia, C\/Dr. Moliner 50, 46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. L.","family":"Miller","sequence":"additional","affiliation":[{"name":"TERTC, University of Houston, College of Optometry, Houston, TX 77204-2020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bergmanson","sequence":"additional","affiliation":[{"name":"TERTC, University of Houston, College of Optometry, Houston, TX 77204-2020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, P.O. Box 8056, 10420 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1350-9462(01)00008-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-0484(03)00022-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000151548.46231.27"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31825240d7"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2010.04.006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3180986299"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-58"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2007.03.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200204000-00020"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.182170"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1159\/000350801"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31821eeaad"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100070044023"},{"issue":"6","key":"16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3928\/1081-597X-19891101-10","volume":"5","year":"1989","journal-title":"Refractive and Corneal Surgery"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1590\/s1807-59322010001200002"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199603000-00006"},{"issue":"5","key":"19","first-page":"473","volume":"15","year":"1996","journal-title":"Cornea"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2004.00272.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3892"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5997"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1788-4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20120531-01"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/832863.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/832863.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/832863.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T01:14:05Z","timestamp":1652318045000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/832863\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":23,"alternative-id":["832863","832863"],"URL":"https:\/\/doi.org\/10.1155\/2015\/832863","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}