{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:21:20Z","timestamp":1779250880714,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic>To evaluate the performance of a computerized-aided method (CaM) for quantification of interstitial lung disease (ILD) in patients with systemic sclerosis and to determine its correlation with the conventional visual reader-based score (CoVR) and the pulmonary function tests (PFTs).<jats:italic>Methods.<\/jats:italic>Seventy-nine patients were enrolled. All patients underwent chest high resolution computed tomography (HRCT) scored by two radiologists adopting the CoVR. All HRCT images were then analysed by a CaM using a DICOM software. The relationships among the lung segmentation analysis, the readers, and the PFTs results were calculated using linear regression analysis and Pearson\u2019s correlation. Receiver operating curve analysis was performed for determination of CaM extent threshold.<jats:italic>Results.<\/jats:italic>A strong correlation between CaM and CoVR was observed (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). The CaM showed a significant negative correlation with forced vital capacity (FVC) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>) and the single breath carbon monoxide diffusing capacity of the lung (DLco) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:math>). A CaM optimal extent threshold of 20% represented the best compromise between sensitivity (75.6%) and specificity (97.4%).<jats:italic>Conclusions.<\/jats:italic>CaM quantification of SSc-ILD can be useful in the assessment of extent of lung disease and may provide reliable tool in daily clinical practice and clinical trials.<\/jats:p>","DOI":"10.1155\/2015\/834262","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T16:47:17Z","timestamp":1420476437000},"page":"1-8","source":"Crossref","is-referenced-by-count":22,"title":["Computer-Aided Quantification of Interstitial Lung Disease from High Resolution Computed Tomography Images in Systemic Sclerosis: Correlation with Visual Reader-Based Score and Physiologic Tests"],"prefix":"10.1155","volume":"2015","author":[{"given":"Fausto","family":"Salaffi","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Polytechnic University of the Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Carotti","sequence":"additional","affiliation":[{"name":"Department of Radiology, Polytechnic University of the Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bosello","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-1760","authenticated-orcid":true,"given":"Alessandro","family":"Ciapetti","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Polytechnic University of the Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-1110","authenticated-orcid":true,"given":"Marwin","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Polytechnic University of the Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Bichisecchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Polytechnic University of the Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianmarco","family":"Giuseppetti","sequence":"additional","affiliation":[{"name":"Department of Radiology, Polytechnic University of the Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Ferraccioli","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, School of Medicine, Catholic University of the Sacred Heart, Rome, 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