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In this review, we will be referring mainly to healing responses in the organs including skin and the lungs.\n                    <jats:italic>Fibrosis<\/jats:italic>\n                    is a process of dysregulated extracellular matrix (ECM) production that leads to a dense and functionally abnormal connective tissue compartment (dermis). In tissues such as the skin, the repair of the dermis after wounding requires not only the\n                    <jats:italic>fibroblasts<\/jats:italic>\n                    that produce the ECM molecules, but also the overlying epithelial layer (\n                    <jats:italic>keratinocytes<\/jats:italic>\n                    ), the\n                    <jats:italic>endothelial cells<\/jats:italic>\n                    , and\n                    <jats:italic>smooth muscle cells<\/jats:italic>\n                    of the blood vessel and white blood cells such as\n                    <jats:italic>neutrophils<\/jats:italic>\n                    and\n                    <jats:italic>macrophages<\/jats:italic>\n                    , which together orchestrate the cytokine-mediated signaling and paracrine interactions that are required to regulate the proper extent and timing of the repair process. This review will focus on the importance of extracellular molecules in the microenvironment, primarily the proteoglycans and glycosaminoglycan hyaluronan, and their roles in wound healing. First, we will briefly summarize the physiological, cellular, and biochemical elements of wound healing, including the importance of cytokine cross-talk between cell types. Second, we will discuss the role of proteoglycans and hyaluronan in regulating these processes. Finally, approaches that utilize these concepts as potential therapies for fibrosis are discussed.\n                  <\/jats:p>","DOI":"10.1155\/2015\/834893","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:20:28Z","timestamp":1441930828000},"page":"1-20","source":"Crossref","is-referenced-by-count":177,"title":["Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Shibnath","family":"Ghatak","sequence":"first","affiliation":[{"name":"Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward V.","family":"Maytin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith 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