{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T05:10:45Z","timestamp":1724821845840},"reference-count":27,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Hydroxyl radical converts Phe to<jats:italic>para<\/jats:italic>-,<jats:italic>meta<\/jats:italic>-, and<jats:italic>ortho<\/jats:italic>-Tyr (<jats:italic>p<\/jats:italic>-Tyr,<jats:italic>m<\/jats:italic>-Tyr,<jats:italic>o<\/jats:italic>-Tyr), while Phe is converted enzymatically to<jats:italic>p<\/jats:italic>-Tyr in the kidney and could serve as substrate for gluconeogenesis. Pathological isoforms<jats:italic>m<\/jats:italic>- and<jats:italic>o<\/jats:italic>-Tyr are supposed to be involved in development of hormone resistances. Role of Phe and the three Tyr isoforms in influencing insulin need was examined in 25 nondiabetic septic patients. Daily insulin dose (DID) and insulin-glucose product (IGP) were calculated. Serum and urinary levels of Phe and Tyr isoforms were determined using a rpHPLC-method. Urinary<jats:italic>m<\/jats:italic>-Tyr\/<jats:italic>p<\/jats:italic>-Tyr ratio was higher in patients with DID and IGP over median compared to those below median (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>, resp.). Urinary<jats:italic>m<\/jats:italic>-Tyr and<jats:italic>m<\/jats:italic>-Tyr\/<jats:italic>p<\/jats:italic>-Tyr ratio showed positive correlation with DID (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.023<\/mml:mn><\/mml:math>, resp.) and with IGP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>, resp.). Serum Phe was a negative predictor, while serum<jats:italic>p<\/jats:italic>-Tyr\/Phe ratio was positive predictor of both DID and IGP. Urinary<jats:italic>m<\/jats:italic>-Tyr and urinary<jats:italic>m<\/jats:italic>-Tyr\/<jats:italic>p<\/jats:italic>-Tyr,<jats:italic>o<\/jats:italic>-Tyr\/<jats:italic>p<\/jats:italic>-Tyr, and (<jats:italic>m<\/jats:italic>-Tyr+<jats:italic>o<\/jats:italic>-Tyr)\/<jats:italic>p<\/jats:italic>-Tyr ratios were positive predictors of both DID and IGP. Phe and Tyr isoforms have a predictive role in carbohydrate metabolism of nondiabetic septic patients. Phe may serve as substrate for renal gluconeogenesis via enzymatically produced<jats:italic>p<\/jats:italic>-Tyr, while hydroxyl radical derived Phe products may interfere with insulin action.<\/jats:p>","DOI":"10.1155\/2015\/839748","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T21:10:34Z","timestamp":1445375434000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Insulin Therapy of Nondiabetic Septic Patients Is Predicted by<i>para<\/i>-Tyrosine\/Phenylalanine Ratio and by Hydroxyl Radical-Derived Products of Phenylalanine"],"prefix":"10.1155","volume":"2015","author":[{"given":"Szil\u00e1rd","family":"Kun","sequence":"first","affiliation":[{"name":"2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of P\u00e9cs, Pacsirta Street 1, P\u00e9cs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerg\u0151 A.","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of P\u00e9cs, Pacsirta Street 1, P\u00e9cs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"S\u00e9lley","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of P\u00e9cs, Pacsirta Street 1, P\u00e9cs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia","family":"Sz\u00e9lig","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of P\u00e9cs, R\u00e1k\u00f3czi Street 2, P\u00e9cs 7623, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Bog\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of P\u00e9cs, R\u00e1k\u00f3czi Street 2, P\u00e9cs 7623, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Csontos","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Faculty of Medicine, University of P\u00e9cs, R\u00e1k\u00f3czi Street 2, P\u00e9cs 7623, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Miseta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine, University of P\u00e9cs, Ifj\u00fas\u00e1g Street 13, P\u00e9cs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Wittmann","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Nephrological Centre, Faculty of Medicine, University of P\u00e9cs, Pacsirta Street 1, P\u00e9cs 7624, 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