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Intestinal ischemia reperfusion (II\/R) injury plays a critical role in remote organ dysfunction, such as lung injury, which is associated with nuclear factor erythroid 2-related factor 2 (Nrf2)\/heme oxygenase-1 (HO-1) signaling pathway. In the present study, we tested whether ginsenoside Rb1 attenuated II\/R induced lung injury by Nrf2\/HO-1 pathway.<jats:italic>Methods<\/jats:italic>. II\/R injury was induced in male C57BL\/6J mice by 45\u2009min of superior mesenteric artery (SMA) occlusion followed by 2 hours of reperfusion. Ginsenoside Rb1 was administrated prior to reperfusion with or without ATRA (all-transretinoic acid, the inhibitor of Nrf2\/ARE signaling pathway) administration before II\/R.<jats:italic>Results<\/jats:italic>. II\/R induced lung histological injury, which is accompanied with increased levels of malondialdehyde (MDA), interleukin- (IL-) 6, and tumor necrosis factor- (TNF-)<jats:italic>\u03b1<\/jats:italic>but decreased levels of superoxide dismutase (SOD) and IL-10 in the lung tissues. Ginsenoside Rb1 reduced lung histological injury and the levels of TNF-<jats:italic>\u03b1<\/jats:italic>and MDA, as well as wet\/dry weight ratio. Interestingly, the increased Nrf2 and HO-1 expression induced by II\/R in the lung tissues was promoted by ginsenoside Rb1 treatment. All these changes could be inhibited or prevented by ATRA.<jats:italic>Conclusion<\/jats:italic>. Ginsenoside Rb1 is capable of ameliorating II\/R induced lung injuries by activating Nrf2\/HO-1 pathway.<\/jats:p>","DOI":"10.1155\/2015\/843721","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T17:03:48Z","timestamp":1434474228000},"page":"1-12","source":"Crossref","is-referenced-by-count":45,"title":["Ginsenoside Rb1 Treatment Attenuates Pulmonary Inflammatory Cytokine Release and Tissue Injury following Intestinal Ischemia Reperfusion Injury in Mice"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-7461","authenticated-orcid":true,"given":"Ying","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan 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