{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:41:23Z","timestamp":1770817283192,"version":"3.50.1"},"reference-count":53,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To assess zinc (Zn) and vitamin D (Vit. D) status in chronic Hepatitis C virus- (HCV) infected patients and their relationship to interleukin- (IL-) 17 and disease severity and then investigate whether Zn and Vit. D3 modulate IL-17 expression in chronic HCV patients.<jats:italic>Methods<\/jats:italic>. Seventy patients and fifty healthy subjects were investigated. Serum levels of Zn, Vit. D, and IL-17 were assessed in the patients group and subgroups. Patients lymphocytes were activated<jats:italic>in vitro<\/jats:italic>in the presence or absence of Zn or Vit. D3 and then intracellular IL-17 production was assessed using flow cytometry.<jats:italic>Results<\/jats:italic>. Zn and Vit. D were significantly decreased in HCV patients. Increasing disease severity leads to more reduction in Zn level opposed by increasing IL-17 level. Zn potently reduced IL-17 production in a dose-related fashion; however it did not exert any toxic effects. Although Vit. D apparently increases IL17 expression, it is unclear whether it is due to its toxic effect on cell count or lack of definite association between Vit. D and both IL-17 and disease severity.<jats:italic>Conclusions<\/jats:italic>. This study demonstrates that Zn modulates IL-17 expression and provides a rationale for evaluating this compound as a supplementary agent in the treatment of chronic HCV.<\/jats:p>","DOI":"10.1155\/2015\/846348","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T11:12:56Z","timestamp":1429009976000},"page":"1-11","source":"Crossref","is-referenced-by-count":14,"title":["The Interplay between Zinc, Vitamin D and, IL-17 in Patients with Chronic Hepatitis C Liver Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Randa","family":"Reda","sequence":"first","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. Box 11566, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal A.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Abbassia Square, P.O. 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