{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:43:18Z","timestamp":1740159798817,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis"],"published-print":{"date-parts":[[2015,2,17]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Early change in rheumatoid arthritis (RA) is characterised by periarticular osteopenia. We investigated the relationship of early metacarpal digital X-ray radiogrammetry bone mineral density (DXR-BMD) change rate (RC-BMD, mg\/cm<jats:sup>2<\/jats:sup>\/month) to longitudinal changes in hand and feet radiographic and wrist MRI scores over 1 year.<jats:italic> Materials and Methods<\/jats:italic>. 10 RA patients completed the study and had wrist 3T-MRI and hand and feet X-rays at various time points over 1 year. MRI was scored by RAMRIS, X-ray was done by van der Heijde modified Sharp scoring, and RC-BMD was analysed using dxr-online.<jats:italic> Results<\/jats:italic>. There was good correlation amongst the two scorers for MRI measures and ICC for erosions: 0.984, BME: 0.943, and synovitis: 0.657. Strong relationships were observed between RC-BMD at 12-week and 1-year change in wrist marrow oedema (BME) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.78<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.035<\/mml:mn><\/mml:math>) but not with erosion, synovitis, or radiographic scores.<jats:italic> Conclusion<\/jats:italic>. Early RC-BMD correlates with 1-year wrist BME change, which is a known predictor of future erosion and joint damage. However, in our pilot study, early RC-BMD did not show relationships to MRI erosion or radiographic changes over 1 year. This may reflect a slower kinetic in the appearance of MRI\/radiographic erosions, generating the hypothesis that RC-BMD may be a more sensitive and early structural prognostic marker in RA follow-up.<\/jats:p>","DOI":"10.1155\/2015\/852989","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T21:03:02Z","timestamp":1424206982000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Early Metacarpal Bone Mineral Density Loss Using Digital X-Ray Radiogrammetry and 3-Tesla Wrist MRI in Established Rheumatoid Arthritis: A Longitudinal One-Year Observational Study"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8461-6539","authenticated-orcid":true,"given":"Anshul","family":"Rastogi","sequence":"first","affiliation":[{"name":"Joint Department of Medical Imaging, Faculty of Medicine, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada M5G 1X5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Algulin","sequence":"additional","affiliation":[{"name":"SECTRA Imtec AB, Teknikringen 20, 583 30 Linkoping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Mangat","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Royal Free Hospital, Pond Street, London NW3 2GQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian K. P.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshthra","family":"Satchithananda","sequence":"additional","affiliation":[{"name":"Department of Radiology, King\u2019s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph V.","family":"Hajnal","sequence":"additional","affiliation":[{"name":"Division of Imaging Sciences, King\u2019s College London, The Rayne Institute, 3rd Floor, Lambeth Wing, St. Thomas\u2019 Hospital, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 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