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Due to its aggressive growth, invasive nature, and the potentially fatal consequences of intracranial complications, acquired cholesteatoma remains a cause of morbidity and death for those who lack access to advanced medical care. Currently, no viable nonsurgical therapies are available. Developing an effective management strategy for this disorder will require a comprehensive understanding of past progress and recent advances. This paper presents a brief review of background issues related to acquired middle ear cholesteatoma and deals with practical considerations regarding the history and etymology of the disorder. We also consider issues related to the classification, epidemiology, histopathology, clinical presentation, and complications of acquired cholesteatoma and examine current diagnosis and management strategies in detail.<\/jats:p>","DOI":"10.1155\/2015\/854024","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T22:08:12Z","timestamp":1426716492000},"page":"1-17","source":"Crossref","is-referenced-by-count":177,"title":["Updates and Knowledge Gaps in Cholesteatoma Research"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5804-8395","authenticated-orcid":true,"given":"Chin-Lung","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Road, Beitou District, Taipei City 11217, Taiwan"},{"name":"Institute of Brain Science, National Yang-Ming University, No. 155, Section 2, Linong Street, Taipei City 11221, Taiwan"},{"name":"Department of Otolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Linong Street, Taipei City 11221, Taiwan"},{"name":"Department of Otolaryngology, Taoyuan Armed Forces General Hospital, No. 168, Zhongxing Road, Longtan District, Taoyuan City 32551, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Suey","family":"Shiao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Road, Beitou District, Taipei City 11217, Taiwan"},{"name":"Department of Otolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Linong Street, Taipei City 11221, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ipswich Hospital NHS Trust, Heath Road, Ipswich, Suffolk IP4 5PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo Prefecture 663-8131, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Sudhoff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Klinikum Bielefeld, Teutoburger Stra\u00dfe 50, 33604 Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-4356","authenticated-orcid":true,"given":"Chih-Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyong-Hsin","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mackay Memorial Hospital, No. 92, Section 2, Zhongshan N. 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