{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:58:57Z","timestamp":1775750337538,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2012\/05\/N\/NZ5\/00882"],"award-info":[{"award-number":["2012\/05\/N\/NZ5\/00882"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Pruritus is one of the major features of lichen planus (LP); however, its pathogenesis remains largely unknown.<jats:italic>Objective<\/jats:italic>. The aim of our study was to analyze the role of IL-31 in the pathogenesis of pruritus in LP.<jats:italic>Materials and Methods<\/jats:italic>. The study group included 22 patients with LP. Control group consisted of 14 healthy volunteers. All subjects underwent thorough examination. Pruritus severity was evaluated with the visual analogue scale (VAS) and the 12-item Itch Questionnaire. IL-31 expression in the skin was assessed using semiquantitative immunofluorescence analysis.<jats:italic>Results<\/jats:italic>. Pruritus maximal intensity according to VAS was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mn>6.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.7<\/mml:mn><\/mml:mrow><\/mml:math>points and according to the 12-item Itch Questionnaire<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mn>6.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>2.8<\/mml:mn><\/mml:mrow><\/mml:math>points. Lesional LP skin showed significantly higher IL-31 expression compared to healthy skin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). The most abundant immunofluorescence was observed within granular layer. However, there was no correlation between expression of IL-31 and pruritus intensity assessed according to VAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>VAS<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>\u03c1<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.08<\/mml:mn><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.73<\/mml:mn><\/mml:mrow><\/mml:math>), as well as 12-item Itch Questionnaire:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>\u03c1<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.11<\/mml:mn><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.65<\/mml:mn><\/mml:mrow><\/mml:math>.<jats:italic>Conclusions<\/jats:italic>. Pruritus is a very common symptom of LP. For the first time we have demonstrated that IL-31 is overexpressed in the lesional skin of LP but its expression does not correlate with intensity of pruritus.<\/jats:p>","DOI":"10.1155\/2015\/854747","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T16:01:05Z","timestamp":1422979265000},"page":"1-6","source":"Crossref","is-referenced-by-count":15,"title":["IL-31 Is Overexpressed in Lichen Planus but Its Level Does Not Correlate with Pruritus Severity"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-0927","authenticated-orcid":true,"given":"Kalina","family":"Welz-Kubiak","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kobuszewska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04062.x"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2340\/00015555-1129","volume":"91","year":"2011","journal-title":"Acta Dermato-Venereologica"},{"issue":"5","key":"3","first-page":"634","volume":"91","year":"2011","journal-title":"Acta Dermato-Venereologica"},{"issue":"20","key":"4","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1523\/JNEUROSCI.17-20-08003.1997","volume":"17","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905605106"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174868"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1950"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700231"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.033"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00405.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00766.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1446"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1265"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.015"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101044"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12222"},{"issue":"1","key":"19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/exd.12587","volume":"24","year":"2015","journal-title":"Experimental Dermatology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.38356"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.047"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01241.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12666"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/all.12316"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1293-6"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1345"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.227"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1527-x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1958"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1191"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.004"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/854747.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/854747.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/854747.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T11:42:52Z","timestamp":1566301372000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2015\/854747\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"alternative-id":["854747","854747"],"URL":"https:\/\/doi.org\/10.1155\/2015\/854747","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}