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All patients received infliximab treatment for 24 weeks. The primary endpoint was ASAS20 response at weeks 12 and 24. The abilities of baseline parameters and response at week 2 to predict ASAS20 response at weeks 12 and 24 were assessed using ROC curve and logistic regression analysis, respectively.<jats:italic>Results.<\/jats:italic>Of 70 axial SpA patients included, the proportions of patients achieving an ASAS20 response at weeks 2, 6, 12, and 24 were 85.7%, 88.6%, 87.1%, and 84.3%, respectively. Baseline MRI sacroiliitis score (AUC = 0.791;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>), CRP (AUC = 0.75;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:math>), and ASDAS (AUC = 0.778,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>) significantly predicted ASAS20 response at week 12. However, only ASDAS (AUC = 0.696,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.040<\/mml:mn><\/mml:math>) significantly predicted ASAS20 response at week 24. Achievement of ASAS20 response after the first infliximab infusion was a significant predictor of subsequent ASAS20 response at weeks 12 and 24 (wald<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn>6.87<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:math>, and wald<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><mml:mo>=<\/mml:mo><mml:mn>5.171<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.023<\/mml:mn><\/mml:math>).<jats:italic>Conclusions.<\/jats:italic>Infliximab shows efficiency in active nonradiographic axial spondyloarthritis patients. ASDAS score and first-dose response could help predicting clinical efficacy of infliximab therapy in these patients.<\/jats:p>","DOI":"10.1155\/2015\/876040","type":"journal-article","created":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T21:03:02Z","timestamp":1437944582000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Predictive Factors of Clinical Response of Infliximab Therapy in Active Nonradiographic Axial Spondyloarthritis Patients"],"prefix":"10.1155","volume":"2015","author":[{"given":"Zhiming","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road No. 600, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zetao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road No. 600, Guangzhou 510630, 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