{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:36:27Z","timestamp":1783488987725,"version":"3.55.0"},"reference-count":26,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Extramammary Paget\u2019s disease (EMPD) is a rare cancer. Although EMPD is usually noninvasive and treated with local therapy, once metastatic the prognosis of EMPD is poor and treatment options are limited. We report a case of a complete response to single agent trastuzumab in a hemodialysis patient with metastatic Her2\/neu overexpressed EMPD of the scrotum. Molecular profiling of his case as well as 12 other EMPD and 8 mammary Paget disease (MPD) cases was completed and revealed multiple biomarker aberrations. Overexpression of Her2 was frequently noted (30%\u201340%) in both EMPD and MPD patients and when present can be effectively treated with Her2 targeted agents. Trastuzumab therapy can be safely utilized in a hemodialysis patient. In addition, multiple protein overexpression and loss were seen in EMPD including PD-1, PD-L1, PTEN, and AR as well as PIK3CA mutation. These findings may lead to possible therapeutic interventions targeting these pathways in a disease with few effective treatment options.<\/jats:p>","DOI":"10.1155\/2015\/895151","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T16:01:57Z","timestamp":1422374517000},"page":"1-7","source":"Crossref","is-referenced-by-count":21,"title":["Metastatic Extramammary Paget\u2019s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature"],"prefix":"10.1155","volume":"2015","author":[{"given":"Peter","family":"Barth","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essel","family":"Dulaimi Al-Saleem","sequence":"additional","affiliation":[{"name":"Department of 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