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However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18<jats:italic>tlr<\/jats:italic>genes and associated signaling factors in four immune-relevant tissues of rainbow trout<jats:italic>Oncorhynchus mykiss<\/jats:italic>. Intraperitoneal injection of a lethal dose of<jats:italic>Aeromonas salmonicida<\/jats:italic>subsp.<jats:italic>salmonicida<\/jats:italic>induced highly increased levels of cytokine mRNAs during a 72-hour postinfection (hpi) period. In contrast, only the fish-specific<jats:italic>tlr22a2<\/jats:italic>and the downstream factor<jats:italic>irak1<\/jats:italic>featured clearly increased transcript levels, while the mRNA concentrations of many other<jats:italic>tlr<\/jats:italic>genes decreased. Flow cytometry quantified cell trafficking after infection indicating a dramatic influx of myeloid cells into the peritoneum and a belated low level immigration of lymphoid cells. T and B lymphocytes were differentiated with RT-qPCR revealing that B lymphocytes emigrated from and T lymphocytes immigrated into head kidney. In conclusion, no specific TLR can be singled out as a dominant receptor for<jats:italic>A. salmonicida<\/jats:italic>. The recruitment of cellular factors of innate immunity rather than induced expression of pathogen receptors is hence of key importance for mounting a first immune defense against invading<jats:italic>A. salmonicida<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2015\/901015","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T17:03:22Z","timestamp":1437584602000},"page":"1-16","source":"Crossref","is-referenced-by-count":28,"title":["<i>Aeromonas salmonicida<\/i>Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (<i>Oncorhynchus mykiss<\/i>)"],"prefix":"10.1155","volume":"2015","author":[{"given":"Andreas","family":"Brietzke","sequence":"first","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, 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