{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T12:11:11Z","timestamp":1649160671551},"reference-count":25,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. No guideline on repeat esophagogastroduodenoscopy (EGD) in functional dyspepsia (FD) exists. This study aimed to define yield, findings, and predictors of positive findings on repeat EGD in FD.<jats:italic>Methods<\/jats:italic>. FD patients who underwent at least 2 EGDs during October 2005 to November 2011 were enrolled and reviewed. Yield and findings were analyzed and univariate and multivariate analyses were performed to identify predictors of positive repeat EGD.<jats:italic>Results<\/jats:italic>. The median time to repeat EGD was 34 months. Among 146 patients, 115 patients (79%) had negative and 31 (21%) had positive repeat EGD, including erosive gastritis (13.0%), peptic ulcer (7.5%), reflux esophagitis (1.4%), and Barrett\u2019s esophagus (0.7%). Four independent predictors of positive repeat EGD were smoking (HR 3.88, 95% CI 1.31\u201311.51,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.015<\/mml:mn><\/mml:math>), hypertension (HR 2.96, 95% CI 1.38\u20136.36,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.050<\/mml:mn><\/mml:math>), history of malignancies (HR 3.65, 95% CI 1.16\u201311.46,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.027<\/mml:mn><\/mml:math>), and antiplatelets or NSAIDs used within 4 weeks (HR 4.10, 95% CI 1.13\u201314.90,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.032<\/mml:mn><\/mml:math>), while alarm features or failure to treatment did not predict positive repeat EGD.\u2009\u2009<jats:italic>Conclusion<\/jats:italic>. Yield of repeat EGD in FD was substantially low, all findings were acid-related disorders, and there was no malignancy. Smoking, hypertension, history of malignancies, and antiplatelets\/NSAIDs use associated with positive repeat EGD.<\/jats:p>","DOI":"10.1155\/2015\/904683","type":"journal-article","created":{"date-parts":[[2015,4,12]],"date-time":"2015-04-12T21:01:22Z","timestamp":1428872482000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Repeat Upper Gastrointestinal Endoscopy in Patients with Functional Dyspepsia: Yield, Findings, and Predictors of Positive Findings"],"prefix":"10.1155","volume":"2015","author":[{"given":"Supot","family":"Pongprasobchai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natta","family":"Asanaleykha","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pongchirat","family":"Tantayakom","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10120, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","first-page":"3","volume":"231","year":"1999","journal-title":"Scandinavian Journal of Gastroenterology, Supplement"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s1542-3565(05)00153-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01897.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.019"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00225.x"},{"issue":"4","key":"6","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.11"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1159\/000358111"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i20.2520"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12090"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"12","first-page":"iv13","volume":"50","year":"2002","journal-title":"Gut"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(00)02553-8"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7344.999"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.13.1606"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.147728"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000108366.19243.3a"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043570"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.05.031"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199701000-00002"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1023\/a:1026040723669"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90138-4"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.04.029"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.736"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.739"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2015\/904683.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2015\/904683.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2015\/904683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T21:33:24Z","timestamp":1469655204000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/grp\/2015\/904683\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":25,"alternative-id":["904683","904683"],"URL":"https:\/\/doi.org\/10.1155\/2015\/904683","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}