{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:17:03Z","timestamp":1790821023267,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T00:00:00Z","timestamp":1443916800000},"content-version":"vor","delay-in-days":276,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum\/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL\u20108, angiogenic factor, and vitamin D is still at the dawn of research. Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL\u20108, and metabolic ones, such as vitamin D. These candidate biomarkers are intended to aid classical biomarkers, such as LDH, in the prognosis of cutaneous melanoma. <jats:italic>Methods.<\/jats:italic> Serum vitamin D and IL\u20108 were quantified in melanoma patients and in matching healthy controls. <jats:italic>Results.<\/jats:italic> Median serum vitamin D concentrations were significantly lower (<jats:italic>p<\/jats:italic> = 0.003) in melanoma patients as compared to healthy control subjects, while around 65% of the investigated patients have proven a severe circulatory deficiency of this vitamin. IL\u20108 was found increased (<jats:italic>p<\/jats:italic> = 0.001) in melanoma patients as compared to controls. <jats:italic>Conclusion.<\/jats:italic> Upregulation of proangiogenic factors associated with vitamin D deficiency can prove to be potent future biomarkers candidates, enhancing the predictive power of classical LDH.<\/jats:p>","DOI":"10.1155\/2015\/904876","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T21:08:15Z","timestamp":1443992895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["25\u2010OH Vitamin D and Interleukin\u20108: Emerging Biomarkers in Cutaneous Melanoma Development and Progression"],"prefix":"10.1155","volume":"2015","author":[{"given":"Corina-Daniela","family":"Ene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia-Elena","family":"Anghel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-2805","authenticated-orcid":false,"given":"Monica","family":"Neagu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilinca","family":"Nicolae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,4]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)90181-3"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308852"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.4161\/15548627.2014.993283"},{"key":"e_1_2_9_4_2","first-page":"186","article-title":"Vitamin-D status at breast cancer diagnosis: correlation with social and environmental factors and dietary intake","volume":"26","author":"Imtiaz S.","year":"2014","journal-title":"Journal of Ayub Medical College Abbottabad"},{"key":"e_1_2_9_5_2","first-page":"1171","article-title":"Vitamin D levels and dietary intake among patients with benign soft tissue tumors and sarcomas","volume":"35","author":"Juzeniene A.","year":"2015","journal-title":"Anticancer Research"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.998838"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112863"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560060309"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.04.011"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202x.2005.23820.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201200018"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4843"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00063.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00203.2010"},{"key":"e_1_2_9_15_2","first-page":"383","article-title":"Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines","volume":"32","author":"Essa S.","year":"2012","journal-title":"Anticancer Research"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11212.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-014-1528-9"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0287"},{"key":"e_1_2_9_19_2","first-page":"86","article-title":"Antibodies against GM1 Gangliosides associated with metastatic melanoma","volume":"21","author":"Nicolae C. 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